N-(4-butylphenyl)-4-fluorobenzenesulfonamide
- CAS No.
- 346692-04-4
- Chemical Name:
- N-(4-butylphenyl)-4-fluorobenzenesulfonamide
- Synonyms
- DC260126;DC260126 >=98% (HPLC);DC260126;DC-260126 ;DC 260126;N-(4-butylphenyl)-4-fluorobenzenesulfonamide;Benzenesulfonamide, N-(4-butylphenyl)-4-fluoro-;stress,DC260126,DC-260126,FFAR,Inhibitor,insulin,inhibit,secretion,Apoptosis,DC 260126,Free Fatty Acid Receptor,phosphorylation,elevation,Ca2+
- CBNumber:
- CB31968223
- Molecular Formula:
- C16H18FNO2S
- Molecular Weight:
- 307.38
- MDL Number:
- MFCD00784423
- MOL File:
- 346692-04-4.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
N-(4-butylphenyl)-4-fluorobenzenesulfonamide price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1050 | DC260126 ≥98% (HPLC) | 346692-04-4 | 5mg | $92.2 | 2024-03-01 | Buy |
Sigma-Aldrich | SML1050 | DC260126 ≥98% (HPLC) | 346692-04-4 | 25mg | $317 | 2022-05-15 | Buy |
Cayman Chemical | 19388 | DC260126 ≥98% | 346692-04-4 | 5mg | $46 | 2024-03-01 | Buy |
Cayman Chemical | 19388 | DC260126 ≥98% | 346692-04-4 | 50 mg | $276 | 2024-03-01 | Buy |
Cayman Chemical | 19388 | DC260126 ≥98% | 346692-04-4 | 1mg | $28 | 2023-01-06 | Buy |
N-(4-butylphenyl)-4-fluorobenzenesulfonamide Chemical Properties,Uses,Production
Description
DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 μM, respectively. At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice.
storage
Store at -20°C
References
1) Hu?et al. (2009),?A novel class of antagonist for the FFAs receptor GPR40; Biochem. Biophys. Res. Commun.,?390?557 2) Zhang?et al. (2010),?DC260126, a small molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats; Biomed. Pharmacother.,?64?647 3) Sun?et al. (2013),?DC260126: a small molecule antagonist of GPR40 that protects against pancreatic β-cells dysfunction in db/db mice; PLoS One.,?8(6)?e66744 4) Wu?et al. (2012), Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis; J. Biochem,?113?1152
N-(4-butylphenyl)-4-fluorobenzenesulfonamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 18361 | 64 |
Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | meilunui@163.com | China | 4673 | 58 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |