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ChemicalBook >> CAS DataBase List >>1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline

1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline

1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline Structure
1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline structure
CAS No.
5234-86-6
Chemical Name:
1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline
Synonyms
Azaquinzole;1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline;2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE;2H-Pyrazino[2,1-a]isoquinoline, 1,3,4,6,7,11bhexahydro-
CBNumber:
CB32389373
Molecular Formula:
C12H16N2
Molecular Weight:
188.27
MDL Number:
MFCD13152230
MOL File:
5234-86-6.mol
Last updated:2022-12-21 16:56:50
Request For Quotation

1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline Properties

storage temp. Keep in dark place,Inert atmosphere,Room temperature
FDA UNII T3H6486135

1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC H949998 2,3,4,6,7,11b-Hexahydro-1H-pyrazino[2,1-a]isoquinoline 5234-86-6 50mg $200 2021-12-16 Buy
AK Scientific 7379AB 2,3,4,6,7,11b-Hexahydro-1H-pyrazino[2,1-a]isoquinoline 5234-86-6 250mg $436 2021-12-16 Buy
Matrix Scientific 178037 1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline dihydrochloride 5234-86-6 0.500g $480 2021-12-16 Buy
American Custom Chemicals Corporation CHM0149309 2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO(2,1-A)ISOQUINOLINE 95.00% 5234-86-6 5MG $495.54 2021-12-16 Buy
Matrix Scientific 178037 1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline dihydrochloride 5234-86-6 1g $600 2021-12-16 Buy
Product number Packaging Price Buy
H949998 50mg $200 Buy
7379AB 250mg $436 Buy
178037 0.500g $480 Buy
CHM0149309 5MG $495.54 Buy
178037 1g $600 Buy

1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline Chemical Properties,Uses,Production

Originator

Azaquinzole,Onbio Inc.

Manufacturing Process

2 Methods of producing of 1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1- a]isoquinoline:
1). 214.0 g diethyl ester of oxalic acid are mixed with a solution of 238.0 g 1- aminomethyl-1,2,3,4-tetrahydroisoquinoline in 200 ml alcohol are boiled for 7 h. After cooling, the obtained crystals of 1,2,3,6,7,11b-hexahydro-4Hpyrazino[ 2,1-a]isoquinoline-3,4-dione are vacuum-filtered and washed with acetone and dried, melting point 220°C. Yield: 240.0 g.
55.0 g lithium aluminum hydride are dissolved in 650 ml absolute tetrahydrofuran and mixed dropwise with a suspension of 120.0 g 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline-3,4-dione in 300 ml absolute tetrahydrofuran. After 7 h of boiling, the residual hydride is decomposed by the addition of water, and the reaction solution is worked up. The obtained 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled in vacuum, boiling point 98°-100°C/0.01 mm. Yield: 86.0 g.
2). 16.2 g 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline and 18.7 g ethylene dibromide are boiled for 4 h in n-butanol, with the addition of 13.8 g potassium carbonate. After the solvent is evaporated, the residue is treated with water, mixed with sodium hydroxide solution, and shaken out with chloroform. The chloroform solution is dried, concentrated by evaporation, and the resulting 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled at 98°-100°C/0.01 mm. The yield amounts to 7.5 g.

Therapeutic Function

CNS depressant

1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline Preparation Products And Raw materials

Raw materials

Sodium hydroxide Lithium Aluminum Hydride 1,2-Dibromoethane 7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Potassium carbonate
Diethyl oxalate 1-Aminomethyl-1, 2, 3, 4-tetrahydroisoquinoline

1of2

Preparation Products

1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9984 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
SynAsst Chemical. 021-60343070 China 12740 55
Shanghai Brain Biotechnology Co., Ltd. 13564638271 sales@brain-biot.com China 2987 55
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 27313 60
BioPharmaMatrix,Inc. 0510-86010668 sales@biopharmamatrix.com China 4208 55
Chengdu Novel Biomedical Co., Ltd. 028-85255396 18302801538 cdnovell@163.com China 2314 58
Aikon International Limited 025-66113011 18112977050 cb6@aikonchem.com China 15494 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
Coresyn Pharmatech Co., Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
SynAsst Chemical. 55
Shanghai Brain Biotechnology Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
BioPharmaMatrix,Inc. 55
Chengdu Novel Biomedical Co., Ltd. 58
Aikon International Limited 58
1,3,4,6,7,11b-Hexahydro-2H-pyrazino[2,1-a]isoquinoline Azaquinzole 2,3,4,6,7,11B-HEXAHYDRO-1H-PYRAZINO[2,1-A]ISOQUINOLINE 2H-Pyrazino[2,1-a]isoquinoline, 1,3,4,6,7,11bhexahydro- 5234-86-6