1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린

1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린 C화학적 특성, 용도, 생산

Originator

Azaquinzole,Onbio Inc.

Manufacturing Process

2 Methods of producing of 1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1- a]isoquinoline:
1). 214.0 g diethyl ester of oxalic acid are mixed with a solution of 238.0 g 1- aminomethyl-1,2,3,4-tetrahydroisoquinoline in 200 ml alcohol are boiled for 7 h. After cooling, the obtained crystals of 1,2,3,6,7,11b-hexahydro-4Hpyrazino[ 2,1-a]isoquinoline-3,4-dione are vacuum-filtered and washed with acetone and dried, melting point 220°C. Yield: 240.0 g.
55.0 g lithium aluminum hydride are dissolved in 650 ml absolute tetrahydrofuran and mixed dropwise with a suspension of 120.0 g 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline-3,4-dione in 300 ml absolute tetrahydrofuran. After 7 h of boiling, the residual hydride is decomposed by the addition of water, and the reaction solution is worked up. The obtained 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled in vacuum, boiling point 98°-100°C/0.01 mm. Yield: 86.0 g.
2). 16.2 g 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline and 18.7 g ethylene dibromide are boiled for 4 h in n-butanol, with the addition of 13.8 g potassium carbonate. After the solvent is evaporated, the residue is treated with water, mixed with sodium hydroxide solution, and shaken out with chloroform. The chloroform solution is dried, concentrated by evaporation, and the resulting 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled at 98°-100°C/0.01 mm. The yield amounts to 7.5 g.

Therapeutic Function

CNS depressant

1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린 준비 용품 및 원자재

원자재

준비 용품

1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
SynAsst Chemical.	021-60343070		China	12742	55
Shanghai Brain Biotechnology Co., Ltd.	13564638271	sales@brain-biot.com	China	2969	55
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	27314	60
BioPharmaMatrix,Inc.	0510-86010668	sales@biopharmamatrix.com	China	3893	55
Chengdu Novel Biomedical Co., Ltd.	028-85255396 18302801538	cdnovell@163.com	China	2288	58
Aikon International Limited	025-66113011 18112977050	cb6@aikonchem.com	China	15495	58