1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린
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1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린 속성
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
안전
1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린 C화학적 특성, 용도, 생산
Originator
Azaquinzole,Onbio Inc.Manufacturing Process
2 Methods of producing of 1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1- a]isoquinoline:1). 214.0 g diethyl ester of oxalic acid are mixed with a solution of 238.0 g 1- aminomethyl-1,2,3,4-tetrahydroisoquinoline in 200 ml alcohol are boiled for 7 h. After cooling, the obtained crystals of 1,2,3,6,7,11b-hexahydro-4Hpyrazino[ 2,1-a]isoquinoline-3,4-dione are vacuum-filtered and washed with acetone and dried, melting point 220°C. Yield: 240.0 g.
55.0 g lithium aluminum hydride are dissolved in 650 ml absolute tetrahydrofuran and mixed dropwise with a suspension of 120.0 g 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline-3,4-dione in 300 ml absolute tetrahydrofuran. After 7 h of boiling, the residual hydride is decomposed by the addition of water, and the reaction solution is worked up. The obtained 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled in vacuum, boiling point 98°-100°C/0.01 mm. Yield: 86.0 g.
2). 16.2 g 1-aminomethyl-1,2,3,4-tetrahydroisoquinoline and 18.7 g ethylene dibromide are boiled for 4 h in n-butanol, with the addition of 13.8 g potassium carbonate. After the solvent is evaporated, the residue is treated with water, mixed with sodium hydroxide solution, and shaken out with chloroform. The chloroform solution is dried, concentrated by evaporation, and the resulting 1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is distilled at 98°-100°C/0.01 mm. The yield amounts to 7.5 g.
Therapeutic Function
CNS depressant1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린 준비 용품 및 원자재
원자재
수산화나트륨
수소화 리튬알미늄
에틸렌 디브롬
7-메톡시-1,2,3,4-테트라히드로-이소퀴놀린염화물
탄산 칼륨
옥살산디에틸
1-Aminomethyl-1, 2, 3, 4-tetrahydroisoquinoline
준비 용품
1,3,4,6,7,11b-헥사히드로-2H-피라지노[2,1-a]이소퀴놀린 공급 업체
글로벌( 22)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 |
cbc@coresyn.com | China | 9991 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131980 | 58 |
SynAsst Chemical. | 021-60343070 |
China | 12742 | 55 | |
Shanghai Brain Biotechnology Co., Ltd. | 13564638271 |
sales@brain-biot.com | China | 2969 | 55 |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 |
3008007409@qq.com | China | 27314 | 60 |
BioPharmaMatrix,Inc. | 0510-86010668 |
sales@biopharmamatrix.com | China | 3893 | 55 |
Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 |
cdnovell@163.com | China | 2288 | 58 |
Aikon International Limited | 025-66113011 18112977050 |
cb6@aikonchem.com | China | 15495 | 58 |