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TRIMIDOX

TRIMIDOX Structure
TRIMIDOX structure
CAS No.
95933-74-7
Chemical Name:
TRIMIDOX
Synonyms
VF 233;TRIMIDOX;Trimidox Exclusive;MSLJYSGFUMYUDX-UHFFFAOYSA-N;N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE;Benzenecarboximidamide, N,3,4,5-tetrahydroxy-;4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one
CBNumber:
CB32446894
Molecular Formula:
C7H8N2O4
Molecular Weight:
184.15
MDL Number:
MFCD02661510
MOL File:
95933-74-7.mol
Last updated:2023-05-21 10:59:17
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TRIMIDOX Properties

storage temp. Store at -20°C
solubility ≤20mg/ml in DMSO;20mg/ml in dimethyl formamide
form crystalline solid
FDA UNII WRR9SR69TE

TRIMIDOX price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10009083 Trimidox ≥98% 95933-74-7 5mg $62 2024-03-01 Buy
Cayman Chemical 10009083 Trimidox ≥98% 95933-74-7 10mg $115 2024-03-01 Buy
Cayman Chemical 10009083 Trimidox ≥98% 95933-74-7 50mg $477 2024-03-01 Buy
Cayman Chemical 10009083 Trimidox ≥98% 95933-74-7 100mg $834 2024-03-01 Buy
TRC T799013 Trimidox 95933-74-7 10mg $145 2021-12-16 Buy
Product number Packaging Price Buy
10009083 5mg $62 Buy
10009083 10mg $115 Buy
10009083 50mg $477 Buy
10009083 100mg $834 Buy
T799013 10mg $145 Buy

TRIMIDOX Chemical Properties,Uses,Production

Description

Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 μM.

Uses

Trimidox is a specific ribonucleotide reductase inhibitor.

Definition

ChEBI: Trimidox is a benzenetriol.

References

[1] szekeres t, fritzer m, strobl h, et al. synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia hl-60 cells[j]. blood, 1994, 84(12): 4316-4321.
[2] elledge s j, zhou z, allen j b. ribonucleotide reductase: regulation, regulation, regulation[j]. trends in biochemical sciences, 1992, 17(3): 119-123.

TRIMIDOX Preparation Products And Raw materials

Raw materials

Preparation Products

TRIMIDOX Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
ApexBio Technology -- sales@apexbt.com United States 6254 58
Supplier Advantage
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Energy Chemical 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
ApexBio Technology 58

95933-74-7(TRIMIDOX)Related Search:

TRIMIDOX N-HYDROXY-3,4,5-TRIMETHOXY-BENZAMIDINE 4,N-DIHYDROXY-BENZAMIDINE
TRIMIDOX VF 233 Trimidox Exclusive MSLJYSGFUMYUDX-UHFFFAOYSA-N 4-[amino-(hydroxyamino)methylidene]-2,6-dihydroxycyclohexa-2,5-dien-1-one Benzenecarboximidamide, N,3,4,5-tetrahydroxy- N,3,4,5-TETRAHYDROXY-BENZENECARBOXIMIDAMIDE 95933-74-7