트리미독스 C화학적 특성, 용도, 생산
개요
Ribonucleotide reductase, the rate-
limiting enzyme for
de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-
60 cells, inducing apoptosis
via activation of caspases without altering the cell cycle distribution. Trimidox inhibits growth of human promyelocytic leukemia HL-
60 cells with an IC
50 value of 35 μM.
용도
Trimidox is a specific ribonucleotide reductase inhibitor.
트리미독스 준비 용품 및 원자재
원자재
준비 용품
