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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride structure

CAS No.: 950912-80-8

Chemical Name:: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

Synonyms: CS-318;PF 67046;PF 670462;PF-670462 HCL;PF-670462 2HCl;PF 670462, >=98%;PF670462/ PF-670462;PF670462 dihydrochloride;PF-670462, 10 mM in DMSO;PF-670462 (hydrochloride)

CBNumber:: CB32518984

Molecular Formula:: C19H20FN5.2HCl

Molecular Weight:: 410

MDL Number:: MFCD12828759

MOL File:: 950912-80-8.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Properties

Melting point	>178°C (dec.)
storage temp.	2-8°C
solubility	H2O: soluble2mg/mL, clear (warmed)
form	powder
color	white to beige
Water Solubility	H2O: 2mg/mL, clear (warmed)
InChIKey	PSNKGVAXBSAHCH-UHFFFAOYSA-N
FDA UNII	D68ANS5I8B
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0795	PF-670462 ≥98% (HPLC)	950912-80-8	5mg	$132	2024-03-01	Buy
Cayman Chemical	14588	PF-670462 (hydrochloride) ≥99%	950912-80-8	10mg	$166	2024-03-01	Buy
Cayman Chemical	14588	PF-670462 (hydrochloride) ≥99%	950912-80-8	50mg	$576	2024-03-01	Buy
Sigma-Aldrich	SML0795	PF-670462 ≥98% (HPLC)	950912-80-8	25mg	$537	2024-03-01	Buy
Tocris	3316	PF670462 ≥99%(HPLC)	950912-80-8	50	$980	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML0795	5mg	$132	Buy
14588	10mg	$166	Buy
14588	50mg	$576	Buy
SML0795	25mg	$537	Buy
3316	50	$980	Buy

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Chemical Properties,Uses,Production

Description

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC₅₀ = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related or common kinases. Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals. It also blocks the locomotor response to amphetamines in mice.

Uses

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selectiv inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).

Biochem/physiol Actions

PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.

storage

room temperature (desiccate)

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Suppliers

Global( 109)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29808	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
BOC Sciences	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Alfa Chemistry	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	PF-670462 950912-80-8	US $68.00-215.00 / mg		99.56%	10g	TargetMol Chemicals Inc.
	2020-03-12	4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride 950912-80-8	US $1.00 / KG	100KG	99.0%	1000kg	Career Henan Chemical Co

PF-670462
950912-80-8
US $68.00-215.00 / mg
99.56%
TargetMol Chemicals Inc.

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
950912-80-8
US $1.00 / KG
99.0%
Career Henan Chemical Co

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Spectrum

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride(950912-80-8)¹HNMR

950912-80-8(4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride)Related Search:

2-FLUOROPHENYL CYCLOPENTYL KETONE TRIS(PENTAFLUOROPHENYL)BORANE

PF670462/ PF-670462 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride 2-PyriMidinaMine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-iMidazol-5-yl]-, hydrochloride (1:2) PF 67046 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride PF670462 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride PF 670462, >=98% PF 670462 PF-670462 2HCl PF-670462 (hydrochloride) Casein Kinase I Inhibitor II, PF-670462 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine:dihydrochloride Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride CS-318 PF670462 dihydrochloride PF-670462 HCL PF 670462, casein kinase 1epsilon (CK1epsilon) and CK1delta inhibitor PF-670462, 10 mM in DMSO 950912-80-8 C19H20FN52HCl C19H22Cl2FN5 C19H20FN52ClH Inhibitors Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators