PD 98059
- CAS No.
- 167869-21-8
- Chemical Name:
- PD 98059
- Synonyms
- 2-(2-AMINO-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE;CS-398;PD090859;PD 98059;PD 098,059;PD 98059 NEW;PD 98059, 99+%;Amino chromone;PD 98059, >=98%;PD-98059/PD98059
- CBNumber:
- CB3256152
- Molecular Formula:
- C16H13NO3
- Molecular Weight:
- 267.28
- MDL Number:
- MFCD00671789
- MOL File:
- 167869-21-8.mol
- MSDS File:
- SDS
Melting point | 164~165℃ |
---|---|
Boiling point | 453.1±45.0 °C(Predicted) |
Density | 1.300±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | ethanol: 0.6 mg/mL |
form | solid |
pka | 1.21±0.10(Predicted) |
color | yellow |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
InChIKey | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
CAS DataBase Reference | 167869-21-8(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | SJE1IO5E3I |
PD 98059 price More Price(65)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P215 | PD 98,059 solid | 167869-21-8 | 1mg | $78.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 513000 | PD 98059 - CAS 167869-21-8 - Calbiochem | 167869-21-8 | 5mg | $159 | 2024-03-01 | Buy |
Sigma-Aldrich | 513001 | InSolution? PD 98059 | 167869-21-8 | 1ml | $172 | 2024-03-01 | Buy |
Sigma-Aldrich | 19-143 | PD 98059 | 167869-21-8 | 5MG | $188 | 2024-03-01 | Buy |
Alfa Aesar | J64485 | 2'-Amino-3'-methoxyflavone, 99% | 167869-21-8 | 10mg | $105.65 | 2024-03-01 | Buy |
PD 98059 Chemical Properties,Uses,Production
Description
PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC50 value of 2-7 μM but does not inhibit Raf-activated MAP2K1. It inhibits Raf activation of MAP2K2 with an IC50 value of 50 μM. PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 μM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).
Uses
PD 98059 is a selective inhibitor of MEK and blocker of MAPK.
Definition
ChEBI: A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'
General Description
Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC50 = 2 μM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.
Biological Activity
Specific inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC 50 = 2-7 μ M). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G 1 arrest by blocking p53-dependent p21 induction. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ .
Biochem/physiol Actions
PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.
storage
Room temperature
References
1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489 2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686 3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366 4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027
PD 98059 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29889 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from PD 98059 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
![]() |
2021-07-02 | 2-(2-aMino-3-Methoxyphenyl)-4H-chroMen-4-one
167869-21-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
![]() |
2019-09-02 | InSolution PD 98059
167869-21-8
|
US $1.00-1.00 / KG | 1KG | 98% | 1lg; 2kg; 5kg; 10kg; 100kg | Career Henan Chemical Co | |
![]() |
2019-09-02 | InSolution PD 98059
167869-21-8
|
US $1.00-1.00 / KG | 1KG | 98% | 1lg; 2kg; 5kg; 10kg; 100kg | Career Henan Chemical Co |
-
- 2-(2-aMino-3-Methoxyphenyl)-4H-chroMen-4-one
167869-21-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- InSolution PD 98059
167869-21-8
- US $1.00-1.00 / KG
- 98%
- Career Henan Chemical Co
-
- InSolution PD 98059
167869-21-8
- US $1.00-1.00 / KG
- 98%
- Career Henan Chemical Co