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CAY10625

CAY10625 Structure
CAY10625 structure
CAS No.
137346-42-0
Chemical Name:
CAY10625
Synonyms
CAY10625;7-nitro-10-octyl-3-phenylpyrimido[4,5-b]quinoline-2,4-dione;Pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, 7-nitro-10-octyl-3-phenyl-
CBNumber:
CB32590447
Molecular Formula:
C25H26N4O4
Molecular Weight:
446.5
MDL Number:
MOL File:
137346-42-0.mol
Last updated:2023-05-21 10:59:17
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CAY10625 Properties

storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.5 mg/ml
form A crystalline solid

CAY10625 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13836 CAY10625 ≥95% 137346-42-0 1mg $82 2024-03-01 Buy
Cayman Chemical 13836 CAY10625 ≥95% 137346-42-0 5mg $362 2024-03-01 Buy
Cayman Chemical 13836 CAY10625 ≥95% 137346-42-0 10mg $642 2024-03-01 Buy
TRC N497008 7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione 137346-42-0 1mg $65 2021-12-16 Buy
TRC N497008 7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione 137346-42-0 2.5mg $130 2021-12-16 Buy
Product number Packaging Price Buy
13836 1mg $82 Buy
13836 5mg $362 Buy
13836 10mg $642 Buy
N497008 1mg $65 Buy
N497008 2.5mg $130 Buy

CAY10625 Chemical Properties,Uses,Production

Description

Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7.1,2 Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO, exhibiting an IC50 value of 2.2 μM.3 It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 μM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.3

Definition

ChEBI: CAY10625 is a nitro compound and a member of quinolines.

References

1. Ryan, B.M., O'Donovan, N., and Duffy, M.J. Survivin: A new target for anti-cancer therapy Cancer Treat. Rev. 35,553-562(2009).
2. Shin, S., Sung, B.J., Cho, Y.S., et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7 Biochemistry 40,1117-1123(2001).
3. Oikawa, T., Unno, Y., Matsuno, K., et al. Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO Biochem. Biophys. Res. Commun. 393,253-258(2010).

CAY10625 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10625 Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7980 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CAY10625 7-nitro-10-octyl-3-phenylpyrimido[4,5-b]quinoline-2,4-dione Pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, 7-nitro-10-octyl-3-phenyl- 137346-42-0