ChemicalBook >> CAS DataBase List >>PHA 408
PHA 408
- CAS No.
- 503555-55-3
- Chemical Name:
- PHA 408
- Synonyms
- PHA 408;PHA-408 >=98% (HPLC);8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide;8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide;1H-Benz[g]indazole-3-carboxamide, 8-[[[5-chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
- CBNumber:
- CB32628254
- Molecular Formula:
- C29H27ClFN7O2
- Molecular Weight:
- 560.02
- MDL Number:
- MFCD17166977
- MOL File:
- 503555-55-3.mol
Last updated:2025-01-27 09:38:02
| Boiling point | 727.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 5mg/mL, clear (warmed) |
| form | powder |
| pka | 10.18±0.20(Predicted) |
| color | white to beige |
| FDA UNII | 8K8XT2KBG3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P305+P351+P338 |
PHA 408 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0266 | PHA-408 ≥98% (HPLC) | 503555-55-3 | 5mg | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0266 | PHA-408 ≥98% (HPLC) | 503555-55-3 | 25mg | $462 | 2024-03-01 | Buy |
| Axon Medchem | Axon1651 | PHA408 99% | 503555-55-3 | 5mg | $115.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0014069 | PHA-408 95.00% | 503555-55-3 | 5MG | $320.1 | 2021-12-16 | Buy |
PHA 408 Chemical Properties,Uses,Production
Biological Activity
PHA-408 is a potent, selective I kappa B-kinase 2 (IKK-2) inhibitor. PHA-408 is a tight binding, ATP competitive IKK-2 inhibitor with greater than 350-fold selectivity for IKK-2 vs IKK-1 (IC50 values of 10-40 nM at IKK-2 vs 14 μM at IKK-1). PHA-408 was shown to suppress inflammatory cellular events, and to reduce inflammation in animal models of arthritis.
PHA 408 Preparation Products And Raw materials
Raw materials
Preparation Products
PHA 408 Suppliers
Global( 11)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4331 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4995 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19699 | 58 |
PHA 408
PHA-408 >=98% (HPLC)
1H-Benz[g]indazole-3-carboxamide, 8-[[[5-chloro-2-(4-methyl-1-piperazinyl)-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-
8-[[5-chloro-2-(4-methylpiperazin-1-yl)pyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide
8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide
503555-55-3
C29H27ClFN7O2