ChemicalBook >> CAS DataBase List >>2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-
2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-
- CAS No.
- 313964-19-1
- Chemical Name:
- 2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-
- Synonyms
- HIF-2α-IN-3;HIF-2α-IN-3;HIF2αIN3,HIF 2α IN 3;N-(4-chloro-3-nitrophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine;2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-
- CBNumber:
- CB32666944
- Molecular Formula:
- C12H6ClN5O5
- Molecular Weight:
- 335.66
- MDL Number:
- MOL File:
- 313964-19-1.mol
Last updated:2024-07-02 08:55:06
Boiling point | 505.6±60.0 °C(Predicted) |
---|---|
Density | 1.726±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO : 12.5 mg/mL (37.24 mM; Need ultrasonic) |
pka | -2.92±0.48(Predicted) |
form | Solid |
color | Light yellow to yellow |
2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Chemical Properties,Uses,Production
Biological Activity
HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent[1]. HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].
References
[1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.
2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Preparation Products And Raw materials
Raw materials
Preparation Products
2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Suppliers
Global( 10)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3770 | 55 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49323 | 58 |
cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10000 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2994 | 58 |
RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9274 | 58 |
2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-
N-(4-chloro-3-nitrophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
HIF-2α-IN-3
HIF-2α-IN-3
HIF2αIN3,HIF 2α IN 3
313964-19-1
C12H6ClN5O5