ChemicalBook >> CAS DataBase List >>2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-

2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-

2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- structure

CAS No.: 313964-19-1

Chemical Name:: 2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-

Synonyms: HIF-2α-IN-3;HIF-2α-IN-3;HIF2αIN3,HIF 2α IN 3;N-(4-chloro-3-nitrophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine;2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-

CBNumber:: CB32666944

Molecular Formula:: C12H6ClN5O5

Molecular Weight:: 335.66

MDL Number:

MOL File:: 313964-19-1.mol

Last updated:2024-07-02 08:55:06

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2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Properties

Boiling point	505.6±60.0 °C(Predicted)
Density	1.726±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 12.5 mg/mL (37.24 mM; Need ultrasonic)
pka	-2.92±0.48(Predicted)
form	Solid
color	Light yellow to yellow

2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0007948	HIF-2α-IN-3 99.52%	313964-19-1	10mg	$550	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0007948	10mg	$550	Buy

2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Chemical Properties,Uses,Production

Biological Activity

HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent[1]. HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1].

References

[1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47.

2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Suppliers

Global( 10)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3770	55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Kaiwei Chemical Technology Co., Ltd.	021-58461859 15821823057	service@aiviche.com	China	49323	58
cjbscvictory	13348960310 13348960310	3003867561@qq.com	China	10000	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	sales@szzxbio.com	China	2994	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9274	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
SPIRO PHARMA	55
Tianjin Kailiqi Biotechnology Co., Ltd.	55
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Shanghai Kaiwei Chemical Technology Co., Ltd.	58
cjbscvictory	58
TargetMol Chemicals Inc.	58
Suzhou Zhixin Biotechnology Co., Ltd.	58
RD International Technology Co., Limited	58

2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- N-(4-chloro-3-nitrophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine HIF-2α-IN-3 HIF-2α-IN-3 HIF2αIN3,HIF 2α IN 3 313964-19-1 C12H6ClN5O5