FOLINIC ACID CALCIUM SALT PENTAHYDRATE

FOLINIC ACID CALCIUM SALT PENTAHYDRATE structure

CAS No.: 41927-89-3

Chemical Name:: FOLINIC ACID CALCIUM SALT PENTAHYDRATE

Synonyms: LEUCOVORIN PENTAHYDRATE;CALCIUM FOLINATE PENTAHYDRATE;LEUCOVORIN CALCIUM SALT PENTAHYDRATE;FOLINIC ACID CALCIUM SALT PENTAHYDRATE;5-HCO-H4PTEGLU CALCIUM SALT PENTAHYDRATE;CITROVORUM FACTOR CALCIUM SALT PENTAHYDRATE;FOLINIC ACID CALCIUM SALT PENTAHYDRATE USP/EP/BP;5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT;5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT PENTAHYDRATE;5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE

CBNumber:: CB3269631

Molecular Formula:: C20H31CaN7O12

Molecular Weight:: 601.58

MDL Number:: MFCD00149465

MOL File:: 41927-89-3.mol

MSDS File:: SDS

Last updated:2023-05-04 15:14:41

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FOLINIC ACID CALCIUM SALT PENTAHYDRATE Properties

Melting point	240-250 °C
storage temp.	0-6°C
solubility	Aqueous (Slightly, Sonicated), Water (Sparingly, Heated, Sonicated)
form	Solid
color	Off-White to Pale Yellow
Stability	Hygroscopic

Pharmacokinetic data

Protein binding	54%
Excreted unchanged in urine	80-90 (as inactive metabolites)
Volume of distribution	17.5(L/kg)
Biological half-life	32-35 minutes / -

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS07
Signal word	Danger
Hazard statements	H335-H319-H334-H317-H315
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P261-P285-P304+P341-P342+P311-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
Safety Statements	24/25

FOLINIC ACID CALCIUM SALT PENTAHYDRATE price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	L2023	Leucovorin Calcium Salt Pentahydrate	41927-89-3	100mg	$418	2021-12-16	Buy
American Custom Chemicals Corporation	ING0006721	CALCIUM FOLINATE PENTAHYDRATE 95.00%	41927-89-3	10MG	$679.14	2021-12-16	Buy
American Custom Chemicals Corporation	ING0006721	CALCIUM FOLINATE PENTAHYDRATE 95.00%	41927-89-3	100MG	$1612.96	2021-12-16	Buy

Product number	Packaging	Price	Buy
L2023	100mg	$418	Buy
ING0006721	10MG	$679.14	Buy
ING0006721	100MG	$1612.96	Buy

FOLINIC ACID CALCIUM SALT PENTAHYDRATE Chemical Properties,Uses,Production

Uses

Anti-anemic (folate deficiency); antidote (to folic acid antagonists).

brand name

Wellcovorin (GlaxoSmithKline).

Clinical Use

Folinic acid rescue
Enhancement of 5-fluorouracil cytotoxicity in advanced colorectal cancer
Folate deficiency

Drug interactions

Potentially hazardous interactions with other drugs Should not be administered simultaneously with a folic acid antagonist as this may nullify the effect of the antagonist.
Cytotoxics: avoid with panitumumab and raltitrexed.

Metabolism

Folinic acid is a racemate where the L-form (L-5- formyl-tetrahydrofolate, L-5-formyl-THF), is the active enantiomer. The major metabolic product of folinic acid is 5-methyl-tetrahydrofolic acid (5-methyl-THF) which is predominantly produced in the liver and intestinal mucosa.
80-90% with the urine (5- and 10-formyltetrahydrofolates inactive metabolites), 5-8% with the faeces.

FOLINIC ACID CALCIUM SALT PENTAHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

FOLINIC ACID CALCIUM SALT PENTAHYDRATE Suppliers

Global( 21)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24727	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2338	56
Hangzhou Bingochem Co., Ltd.	0571-8512-5372	sales@bingochem.com	China	21669	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Dideu Industries Group Limited	58
LEAP CHEM CO., LTD.	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
TAIYUAN RHF CO.,LTD.	56
Hangzhou Bingochem Co., Ltd.	58

View Lastest Price from FOLINIC ACID CALCIUM SALT PENTAHYDRATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-31	FOLINIC ACID CALCIUM SALT PENTAHYDRATE USP/EP/BP 41927-89-3	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited

FOLINIC ACID CALCIUM SALT PENTAHYDRATE USP/EP/BP
41927-89-3
US $1.10 / g
99.9%
Dideu Industries Group Limited

41927-89-3(FOLINIC ACID CALCIUM SALT PENTAHYDRATE)Related Search:

L-Tetrahydrofolic Acid Folinic acid Folinic acid, calcium salt pentahydrate, 95.0-105.0% N-(p-Aminobenzoyl)glutamic acid Pteridine, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI)

2,4-Diamino-6-hydroxypyrimidine BZ-GLU-OH Calcium folinate (S)-N-BENZYLGLUTAMIC ACID 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE

FOLINIC ACID CALCIUM SALT PENTAHYDRATE N-(4-Aminobenzoyl)-DL-glutamic acid 2,4,5-TRIAMINOPYRIMIDINE 5-Pyrimidinamine, N-methyl- (9CI) 6-AMINO-5-FORMYLAMINO-3H-PYRIMIDINE-4-ONE

2,4-Diamino-6-hydroxypyrimidine ,98% Calcium Folinate Pentahydrate

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5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT 5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT PENTAHYDRATE 5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE 5-HCO-H4PTEGLU CALCIUM SALT PENTAHYDRATE CALCIUM FOLINATE PENTAHYDRATE LEUCOVORIN CALCIUM SALT PENTAHYDRATE LEUCOVORIN PENTAHYDRATE FOLINIC ACID CALCIUM SALT PENTAHYDRATE CITROVORUM FACTOR CALCIUM SALT PENTAHYDRATE N5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE FOLINIC ACID CALCIUM SALT PENTAHYDRATE USP/EP/BP 41927-89-3