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WH-4-023

WH-4-023 structure

CAS No.: 837422-57-8

Chemical Name:: WH-4-023

Synonyms: KIN112;CS-1827;WH-4-023;WH-4-024;KIN001-112;WH-4-023, >=98%;)(2-((4-(4-methyL;WH-4-023 USP/EP/BP;WH-4-023, 837422-57-8;)amino)pyrimidin-4-yL

CBNumber:: CB32710784

Molecular Formula:: C32H36N6O4

Molecular Weight:: 568.67

MDL Number:: MFCD28138072

MOL File:: 837422-57-8.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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WH-4-023 Properties

Boiling point	743.2±70.0 °C(Predicted)
Density	1.247±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (60 mg/ml)
pka	7.89±0.42(Predicted)
form	powder
color	white to beige
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310-P405-P501

RIDADR

UN 2811 6.1 / PGIII

NFPA 704

	0
2		0

WH-4-023 price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1334	WH-4-023 ≥98% (HPLC)	837422-57-8	5mg	$146	2024-03-01	Buy
Sigma-Aldrich	SML1334	WH-4-023 ≥98% (HPLC)	837422-57-8	25mg	$564	2023-01-07	Buy
Cayman Chemical	9002067	WH-4-023 ≥98%	837422-57-8	1mg	$39	2024-03-01	Buy
Cayman Chemical	9002067	WH-4-023 ≥98%	837422-57-8	5mg	$115	2024-03-01	Buy
Cayman Chemical	9002067	WH-4-023 ≥98%	837422-57-8	10mg	$172	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1334	5mg	$146	Buy
SML1334	25mg	$564	Buy
9002067	1mg	$39	Buy
9002067	5mg	$115	Buy
9002067	10mg	$172	Buy

WH-4-023 Chemical Properties,Uses,Production

Description

WH-4-23 (837422-57-8) is a potent and selective inhibitor of Src family kinases Lck and Src, IC50=2 and 6 nM respectively.1,2 Also inhibits SIK, IC50=10, 22 and 60 nM for SIK 1, 2 and 3 respectively.3 May be used along with PD-325901 and CHIR-99021 to support self-renewal of na?ve human embryonic stem cells.4

Uses

WH-4-023 is a potent and selective dual lymphocyte-specific kinase (Lck) inhibitor.

Definition

ChEBI: N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]carbamic acid (2,6-dimethylphenyl) ester is a member of piperazines.

Biochem/physiol Actions

WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM for SIK 1, 2 and 3 respectively. WH-4-023 was found to support self-renewal of naive human embryonic stem cells, in particular in combination with PD 0325901 (PZ0162), CHIR99021 (SML1046), and SB-590885 (SML0501).

storage

Store at -20°C

References

Martin et al. (2006), Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity; J. Med. Chem., 49 4981 Moroco et al. (2015), A discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region; Chem. Biol. Drug. Des., 86 144 Clark et al. (2012), Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages; Proc. Natl. Acad. Sci. USA, 109 16986 Theunissen et al. (2014), Systemic identification of culture conditions for introduction and maintenance of na?ve human pluripotency; Cell Stem Cell, 15 471

WH-4-023 Preparation Products And Raw materials

Raw materials

Preparation Products

WH-4-023 Suppliers

Global( 118)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22784	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Henan Alfa Chemical Co., Ltd			China	10947	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9984	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
Henan Alfa Chemical Co., Ltd	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58

View Lastest Price from WH-4-023 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	WH-4-023 837422-57-8	US $47.00-101.00 / mg		99.75%	10g	TargetMol Chemicals Inc.
	2019-09-05	2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE 837422-57-8	US $1.00 / ASSAYS	1ASSAYS	96%	10kg	Career Henan Chemical Co

WH-4-023
837422-57-8
US $47.00-101.00 / mg
99.75%
TargetMol Chemicals Inc.

2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE
837422-57-8
US $1.00 / ASSAYS
96%
Career Henan Chemical Co

WH-4-023 Spectrum

WH-4-023(837422-57-8)¹HNMR

837422-57-8(WH-4-023)Related Search:

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JAK3 INHIBITOR I 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

Y27632 (hydrochloride) Saracatinib SB590885 PD 0325901 IM-12

Olaparib

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2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE Carbamic acid, N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-, 2,6-dimethylphenyl ester KIN001-112 KIN112 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate WH-4-023 WH-4-023 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE WH-4-023, >=98% WH-4-023, 837422-57-8 2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin- 2,6-Dimethylphenyl N-[2,4-bis(methyloxy)phenyl][2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate WH-4-023 DUAL LCK/SRC INHIBITOR CS-1827 WH-4-024 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate DUAL LCK/SRC INHIBITOR;KIN001-112; KIN112 )(2-((4-(4-methyL )amino)pyrimidin-4-yL 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)carbamate WH-4-023 USP/EP/BP 837422-57-8 Inhibitors API