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JX401

CAS No.
349087-34-9
Chemical Name:
JX401
Synonyms
JX401;p38 MAP Kinase Inhibitor VI, JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem;Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]-
CBNumber:
CB01074327
Molecular Formula:
C21H25NO2S
Molecular Weight:
355.49
MDL Number:
MFCD02038777
MOL File:
349087-34-9.mol
Last updated:2024-10-28 16:48:35

JX401 Properties

storage temp. Store at RT
solubility Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
form Off-white solid
color White
Stability Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
FDA UNII TBU7UTV30Q

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P391-P501
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9/PG 3

JX401 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 506157 p38 MAP Kinase Inhibitor VI, JX401 349087-34-9 5mg $251 2023-06-20 Buy
Cayman Chemical 16898 JX-401 ≥95% 349087-34-9 1mg $57 2024-03-01 Buy
Cayman Chemical 16898 JX-401 ≥95% 349087-34-9 5mg $111 2024-03-01 Buy
Cayman Chemical 16898 JX-401 ≥95% 349087-34-9 10mg $193 2024-03-01 Buy
Cayman Chemical 16898 JX-401 ≥95% 349087-34-9 50mg $820 2024-03-01 Buy
Product number Packaging Price Buy
506157 5mg $251 Buy
16898 1mg $57 Buy
16898 5mg $111 Buy
16898 10mg $193 Buy
16898 50mg $820 Buy

JX401 Chemical Properties,Uses,Production

Description

JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.

Uses

JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]

Uses

JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.

Definition

ChEBI: [2-methoxy-4-(methylthio)phenyl]-[4-(phenylmethyl)-1-piperidinyl]methanone is a N-acylpiperidine and a member of benzamides.

Biological Activity

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

storage

Room temperature

References

1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.

JX401 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 61)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58

View Lastest Price from JX401 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JX 401 pictures 2024-10-28 JX 401
349087-34-9
US $143.00-483.00 / mg 10g TargetMol Chemicals Inc.
  • JX 401 pictures
  • JX 401
    349087-34-9
  • US $143.00-483.00 / mg
  • TargetMol Chemicals Inc.
JX401 1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine p38 MAP Kinase Inhibitor VI, JX401 p38 MAP Kinase Inhibitor VI, JX401 - CAS 349087-34-9 - Calbiochem Methanone, [2-methoxy-4-(methylthio)phenyl][4-(phenylmethyl)-1-piperidinyl]- 349087-34-9 Intracellular Signaling