SB 202190 | 152121-30-7

SB 202190 Properties

Melting point	240-243℃
Boiling point	565.7±50.0 °C(Predicted)
Density	1.31
RTECS	SL4584000
storage temp.	2-8°C
solubility	DMSO: 30 mg/mL, soluble
pka	9.14±0.15(Predicted)
form	Pale yellow solid
color	pale yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey	QHKYPYXTTXKZST-UHFFFAOYSA-N
FDA UNII	PVX798P8GI
UNSPSC Code	12352202
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

3

HS Code

29333990

NFPA 704

	0
2		0

SB 202190 price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	559397	InSolution? SB 202190	152121-30-7	1ml	$201	2024-03-01	Buy
Sigma-Aldrich	559388	SB 202190	152121-30-7	1mg	$159	2024-03-01	Buy
Alfa Aesar	J60950	SB 202190, 99+%	152121-30-7	25mg	$131	2023-06-20	Buy
Alfa Aesar	J60950	SB 202190, 99+%	152121-30-7	50mg	$258	2023-06-20	Buy
Cayman Chemical	10010399	SB 202190 ≥98%	152121-30-7	10mg	$29	2024-03-01	Buy

Product number	Packaging	Price	Buy
559397	1ml	$201	Buy
559388	1mg	$159	Buy
J60950	25mg	$131	Buy
J60950	50mg	$258	Buy
10010399	10mg	$29	Buy

SB 202190 Chemical Properties,Uses,Production

Description

SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. When tested at 10 μM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs, JNKs). Pyridinyl imidazole inhibitors, including this compound, directly bind p38 MAP kinases in the ATP binding pocket. Recently, SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.

Uses

SB 202190 is a DFG inhibitor used in the treatment of colorectal cancer. It is a highly selective, potent inhibitor of p38 MAP kinase. SB-202190 is able to promote proliferation of C6 cells in lower concentration but induced apoptosis in higher levels. Studies show that SB202190 can protect neural function from ischemia/reperfusion injury and regulate the activation of Bcl-2 and Bax protein after ischemia/reperfusion in rat.

Definition

ChEBI: A member of the class of imidazoles that is 1H-imidazole in which the hydrogens at positions 2, 4, and 5 are replaced by 4-hydroxyphenyl, pyridin-4-yl, and 4-fluorophenyl groups, respectively. It is a widely used inhibitor of mitogen-act vated protein kinase (MAPK) alpha and beta.

General Description

A potent, reversible, competitive, and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (K_i = 16 nM; IC₅₀ = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC₅₀ = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to induce LDL receptor expression in Hep52 cells. A 1 mg/ml solution of SB 202190 (Cat. No. 559397) in anhydrous DMSO is also available.

Biological Activity

A highly selective, potent and cell-permeable inhibitor of p38 MAP kinase. Binds within the ATP pocket of the active kinase (K d = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38 α and β isoforms (IC 50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Also available as part of the MAPK Inhibitor Tocriset™ .

Biochem/physiol Actions

Cell permeable: yes

storage

-20°C

References

1) Young et al. (1997), Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site; J. Biol. Chem., 272 12116 2) Davies et al. (2000), Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95 3) Manthey et al. (1998), SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRBAs in monocytes; J. Leukoc. Biol., 64 409 4) Nemoto et al. (1998), Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase; J. Biol. Chem., 273 16415

SB 202190 synthesis

Synthesis of SB 202190 from 4-Fluorobenzoyl chloride

SB 202190 Preparation Products And Raw materials

Raw materials

2-(tert-butyldimethyl-silyloxy)-1-(4-fluorophenyl)-2-pyridin-4-yl-ethanone 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE 4-(TERT-BUTYLDIMETHYLSILYLOXYMETHYL)PYRIDINE 4-Fluoro-N-methoxy-N-methylbenzamide 4-Fluorobenzoyl chloride

4-Methylpyridine 4-Hydroxybenzaldehyde

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Preparation Products

SB 202190 Suppliers

Global( 226)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29730	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-+86-371-66670886	info@dakenam.com	China	19805	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29858	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32202	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22854	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58

View Lastest Price from SB 202190 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-28	SB 202190 152121-30-7	US $35.00-87.00 / mg		99.67%	10g	TargetMol Chemicals Inc.
2021-09-27	SB 202190 152121-30-7	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2019-07-06	SB 202190 152121-30-7	US $1.00 / KG	1KG	98-100%	1000kg	Career Henan Chemical Co

SB 202190
152121-30-7
US $35.00-87.00 / mg
99.67%
TargetMol Chemicals Inc.

SB 202190
152121-30-7
US $1.10 / g
99.00%
Dideu Industries Group Limited

SB 202190
152121-30-7
US $1.00 / KG
98-100%
Career Henan Chemical Co

SB 202190 Spectrum

SB 202190(152121-30-7)¹HNMR

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1of4

4-[4-(4-FLUOROPHENYL)-5-(4-PYRIDINYL)-1H-IMIDAZOL-2-YL]PHENOL 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)-1H-IMIDAZOLE 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-2H-imidazol-2-yl)phenol Aids110355 Aids-110355 Phenol, 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]- SB 202190 SB 202190,4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole 4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-iMidazol-2-yl)phenol 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole SB 202190 SB202109 SB 202190, >=98% InSolution? SB 202190 SB202190 (FHPI) CS-403 2-(2-allylcarbamoylimino-5-nitro-thiazol-3-yl)-N-carbamoyl-acetamide InSolution SB 202190 - CAS 152121-30-7 - Calbiochem SB 202190 - CAS 152121-30-7 - Calbiochem CS-1907 CS-1908 SB-202190; SB 202190 2-(4-hydroxy-phenyl-)-4-(4-fluoro-phenyl-)-5-(pyrid-4-yl)-imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(pyridin-4-yl)-1H-imidazole SB 202190 ISO 9001：2015 REACH AI3 02281 AI302281 AI3-02281 FHPI 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydro-2H-imidazol-2-ylidene]cyclohexa-2,5-dien-1-one 4-[4-(4-Fluorophenyl)-5-(4-pyridyl)-2-imidazolyl]phenol SB 202190, cell-permeable p38 MAPK inhibitor SB 202190, 10 mM in DMSO 152121-30-7 52121-30-7 C20H14FN3O C20H14N3OF Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors p38 Mitogen-Activated protein kinase (p38MAPK) BioChemical Cell Signaling and Neuroscience Cell Biology Inhibitors inhibitor