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MPI-0479605

MPI-0479605 structure

CAS No.: 1246529-32-7

Chemical Name:: MPI-0479605

Synonyms: CS-1459;MPI-0479605;MPI0479605 HCl;MPI-0479605 USP/EP/BP;MPI-0479605;MPI 0479605;MPI0479605;N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine;N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine;9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?-

CBNumber:: CB32731101

Molecular Formula:: C22H29N7O

Molecular Weight:: 407.51

MDL Number:: MFCD28099811

MOL File:: 1246529-32-7.mol

Last updated:2024-07-02 08:55:06

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MPI-0479605 Properties

Boiling point	745.8±70.0 °C(Predicted)
Density	1.318±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Soluble in DMSO
form	A crystalline solid
pka	10.52±0.10(Predicted)
color	White to gray

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235

NFPA 704

	0
2		0

MPI-0479605 price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22136	MPI-0479605 ≥98%	1246529-32-7	1mg	$57	2024-03-01	Buy
Cayman Chemical	22136	MPI-0479605 ≥98%	1246529-32-7	5mg	$233	2024-03-01	Buy
Cayman Chemical	22136	MPI-0479605 ≥98%	1246529-32-7	10mg	$437	2024-03-01	Buy
Cayman Chemical	22136	MPI-0479605 ≥98%	1246529-32-7	25mg	$957	2024-03-01	Buy
AK Scientific	2574AH	N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine	1246529-32-7	1g	$1246	2021-12-16	Buy

Product number	Packaging	Price	Buy
22136	1mg	$57	Buy
22136	5mg	$233	Buy
22136	10mg	$437	Buy
22136	25mg	$957	Buy
2574AH	1g	$1246	Buy

MPI-0479605 Chemical Properties,Uses,Production

Description

MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC₅₀ = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole . It also causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity. MPI-0479605 (30-150 mg/kg) reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner.

References

[1] tardif k d, rogers a, cassiano j, et al. characterization of the cellular and antitumor effects of mpi-0479605, a small-molecule inhibitor of the mitotic kinase mps1. molecular cancer therapeutics, 2011, 10(12): 2267-2275.

MPI-0479605 Preparation Products And Raw materials

Raw materials

Preparation Products

MPI-0479605 Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32760	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	25247	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58

View Lastest Price from MPI-0479605 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-26	MPI-0479605 1246529-32-7	US $1.00 / KG	1KG	97%-99.9%	100kg	Career Henan Chemical Co

MPI-0479605
1246529-32-7
US $1.00 / KG
97%-99.9%
Career Henan Chemical Co

MPI-0479605 Spectrum

MPI-0479605(1246529-32-7)¹HNMR

1246529-32-7(MPI-0479605)Related Search:

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3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide

1of2

MPI-0479605 N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine MPI0479605 HCl N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine MPI-0479605;MPI 0479605;MPI0479605 9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?- CS-1459 MPI-0479605 USP/EP/BP 1246529-32-7 C22H29N7O Inhibitors