ChemicalBook >> CAS DataBase List >>MPI-0479605

MPI-0479605

CAS No.
1246529-32-7
Chemical Name:
MPI-0479605
Synonyms
CS-1459;MPI-0479605;MPI0479605 HCl;MPI-0479605 USP/EP/BP;MPI-0479605;MPI 0479605;MPI0479605;N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine;N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine;9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?-
CBNumber:
CB32731101
Molecular Formula:
C22H29N7O
Molecular Weight:
407.51
MDL Number:
MFCD28099811
MOL File:
1246529-32-7.mol
Last updated:2024-11-19 20:33:22

MPI-0479605 Properties

Boiling point 745.8±70.0 °C(Predicted)
Density 1.318±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO
form A crystalline solid
pka 10.52±0.10(Predicted)
color White to gray

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS02
Signal word  Warning
Hazard statements  H226
Precautionary statements  P501-P240-P210-P233-P243-P241-P242-P280-P370+P378-P303+P361+P353-P403+P235
NFPA 704
0
2 0

MPI-0479605 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 1246529-32-7 1mg $57 2024-03-01 Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 1246529-32-7 5mg $233 2024-03-01 Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 1246529-32-7 10mg $437 2024-03-01 Buy
Cayman Chemical 22136 MPI-0479605 ≥98% 1246529-32-7 25mg $957 2024-03-01 Buy
AK Scientific 2574AH N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine 1246529-32-7 1g $1246 2021-12-16 Buy
Product number Packaging Price Buy
22136 1mg $57 Buy
22136 5mg $233 Buy
22136 10mg $437 Buy
22136 25mg $957 Buy
2574AH 1g $1246 Buy

MPI-0479605 Chemical Properties,Uses,Production

Description

MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC50 = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole . It also causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity. MPI-0479605 (30-150 mg/kg) reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner.

References

[1] tardif k d, rogers a, cassiano j, et al. characterization of the cellular and antitumor effects of mpi-0479605, a small-molecule inhibitor of the mitotic kinase mps1. molecular cancer therapeutics, 2011, 10(12): 2267-2275.

MPI-0479605 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 90)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28172 58
Alchem Pharmtech,Inc.
8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 22785 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43340 58

View Lastest Price from MPI-0479605 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MPI-0479605 pictures 2024-11-19 MPI-0479605
1246529-32-7
US $54.00-213.00 / mg 99.23% 10g TargetMol Chemicals Inc.
MPI-0479605 pictures 2019-12-26 MPI-0479605
1246529-32-7
US $1.00 / KG 1KG 97%-99.9% 100kg Career Henan Chemical Co
  • MPI-0479605 pictures
  • MPI-0479605
    1246529-32-7
  • US $54.00-213.00 / mg
  • 99.23%
  • TargetMol Chemicals Inc.
  • MPI-0479605 pictures
  • MPI-0479605
    1246529-32-7
  • US $1.00 / KG
  • 97%-99.9%
  • Career Henan Chemical Co

MPI-0479605 Spectrum

MPI-0479605 N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine MPI0479605 HCl N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine MPI-0479605;MPI 0479605;MPI0479605 9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?- CS-1459 MPI-0479605 USP/EP/BP 1246529-32-7 C22H29N7O Inhibitors