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PF-05139962
- CAS No.
- 1393712-18-9
- Chemical Name:
- PF-05139962
- Synonyms
- PF-05139962;Urea, N-[4-[7,8-dihydro-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxido-5H-thiopyrano[4,3-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
- CBNumber:
- CB32731121
- Molecular Formula:
- C21H27N5O4S
- Molecular Weight:
- 445.54
- MDL Number:
- MOL File:
- 1393712-18-9.mol
Last updated:2023-03-31 09:12:58
PF-05139962 Chemical Properties,Uses,Production
Description
PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in a very desirable range for a kinase inhibitor.
PF-05139962 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-05139962 Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6357 | 58 | |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28118 | 58 |
| Supplier | Advantage |
|---|---|
| Jinan elephant international trading co., LTD | 58 |
| TargetMol Chemicals Inc. | 58 |
PF-05139962
Urea, N-[4-[7,8-dihydro-4-[(3S)-3-methyl-4-morpholinyl]-6,6-dioxido-5H-thiopyrano[4,3-d]pyrimidin-2-yl]phenyl]-N'-ethyl-
1393712-18-9