9H-Pyrido[3,4-b]indole-1-carboxylic acid
![9H-Pyrido[3,4-b]indole-1-carboxylic acid
Structure](CAS/20180703/GIF/26052-96-0.gif)
- CAS No.
- 26052-96-0
- Chemical Name:
- 9H-Pyrido[3,4-b]indole-1-carboxylic acid
- Synonyms
- β-Carboline-1-carboxylic Acid;??-Carboline-1-carboxylic acid;Carboline 1-carboxylic acid, β-;9H-pyrido[3,4-b]indol-1-carboxylic acid;9H-Pyrido[3,4-b]indole-1-carboxylic acid
- CBNumber:
- CB33076827
- Molecular Formula:
- C12H8N2O2
- Molecular Weight:
- 212.2
- MDL Number:
- MOL File:
- 26052-96-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H302-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
9H-Pyrido[3,4-b]indole-1-carboxylic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B530605 | 9H-pyrido[3,4-b]indole-1-carboxylicAcid | 26052-96-0 | 100mg | $265 | 2021-12-16 | Buy |
| AK Scientific | 9928CV | 9H-Pyrido[3,4-b]indole-1-carboxylicacid | 26052-96-0 | 100mg | $328 | 2021-12-16 | Buy |
| AccelPharmtech | P5040 | 9H-Pyrido[3,4-b]indole-1-carboxylicacid 97.00% | 26052-96-0 | 1G | $2280 | 2021-12-16 | Buy |
| AccelPharmtech | P5040 | 9H-Pyrido[3,4-b]indole-1-carboxylicacid 97.00% | 26052-96-0 | 5G | $3900 | 2021-12-16 | Buy |
| AccelPharmtech | P5040 | 9H-Pyrido[3,4-b]indole-1-carboxylicacid 97.00% | 26052-96-0 | 25G | $7320 | 2021-12-16 | Buy |
9H-Pyrido[3,4-b]indole-1-carboxylic acid Chemical Properties,Uses,Production
Biological Activity
β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities.1,2,3 It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 μg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells.2 β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 μg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 μg/ml, respectively).1 It also inhibits cAMP phosphodiesterase with an IC50 value of 96 μM.3
References
1.Lai, Z.-Q., Liu, W.-H., Ip, S.-P., et al.Seven alkaloids from Picrasma quassioides and their cytotoxic activitiesChem. Nat. Compd.50(5)884-888(2014) 2.Cui, Y., Jiang, L., Yu, R., et al.β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transitionJ. Ethnopharmacol.243112096(2019) 3.Sung, Y.-I., Koike, K., Nikaido, T., et al.Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides BENNET, and inhibitory activities of related β-carboline alkaloidsChem. Pharm. Bull. (Tokyo)32(5)1872-1877(1984)
9H-Pyrido[3,4-b]indole-1-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
9H-Pyrido[3,4-b]indole-1-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 19172 | 64 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14055 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| AnEasyTech Shanghai Co., Ltd. | 021-62960002 13916181326 | sales@aneasytech.com | China | 229 | 58 |
| ChemeGen 中国 | 18818260767 | 2625930290@qq.com | China | 6973 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 39990 | 58 |
| Shanghai Saikerui Biotechnology Co. , Ltd. | 021-58000709 15900491054 | info@scrbio.com | China | 10329 | 58 |
| 4008-099-669 | 23419001name@qq.com | CHINA | 71677 | 58 |