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G-5555

CAS No.
1648863-90-4
Chemical Name:
G-5555
Synonyms
G-5555;G5555;G 5555;PAK1 inhibitor (g-5555);p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555;8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met;8-((trans-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-
CBNumber:
CB33126700
Molecular Formula:
C25H25ClN6O3
Molecular Weight:
492.96
MDL Number:
MFCD28506227
MOL File:
1648863-90-4.mol
Last updated:2024-11-19 20:33:22

G-5555 Properties

Boiling point 684.6±65.0 °C(Predicted)
Density 1.363±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form A crystalline solid
pka 6.86±0.40(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

G-5555 price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3237 G-5555 ≥98% (HPLC) 1648863-90-4 5MG $102 2023-06-20 Buy
Sigma-Aldrich SML3237 G-5555 ≥98% (HPLC) 1648863-90-4 25MG $409 2023-06-20 Buy
Cayman Chemical 21469 G-5555 ≥98% 1648863-90-4 500μg $44 2024-03-01 Buy
Cayman Chemical 21469 G-5555 ≥98% 1648863-90-4 1mg $79 2024-03-01 Buy
Cayman Chemical 21469 G-5555 ≥98% 1648863-90-4 5mg $330 2024-03-01 Buy
Product number Packaging Price Buy
SML3237 5MG $102 Buy
SML3237 25MG $409 Buy
21469 500μg $44 Buy
21469 1mg $79 Buy
21469 5mg $330 Buy

G-5555 Chemical Properties,Uses,Production

Description

G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50 values ranging from 9 to 52 nM. G-5555 inhibits phosphorylation of MEK, a downstream target of PAK1, in EBC1 cells (IC50 = 69 nM). G-5555 (10, 20, and 30 mg/kg) dose-dependently reduces phosphorylation of MEK in tumors from an H292 non-small cell lung cancer (NSCLC) mouse xenograft model. G-5555 inhibits hERG channels less than 50% at a concentration of 10 μM, indicating the potential for a low risk of QT interval prolongation and potentially fatal arrhythmias.

Uses

G 5555 is a high affinity group 1 p21-activated kinases (PAK) inhibitor.

storage

Store at -20°C

G-5555 Preparation Products And Raw materials

Raw materials

Preparation Products

G-5555 Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38632 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131957 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Heze Development Zone chuangli Chemical Co., Ltd. +86-530-529 6766,+86-15666160102 15666160102 info@chuangli-chem.com China 894 55
Musechem +1-800-259-7612 info@musechem.com United States 4660 60
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58

View Lastest Price from G-5555 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
G-5555 pictures 2024-11-19 G-5555
1648863-90-4
US $48.00-89.00 / mg 99.76% 10g TargetMol Chemicals Inc.
G-5555 pictures 2024-11-19 G-5555
1648863-90-4
US $48.00-89.00 / mg 99.76% 10g TargetMol Chemicals Inc.
  • G-5555 pictures
  • G-5555
    1648863-90-4
  • US $48.00-89.00 / mg
  • 99.76%
  • TargetMol Chemicals Inc.
  • G-5555 pictures
  • G-5555
    1648863-90-4
  • US $48.00-89.00 / mg
  • 99.76%
  • TargetMol Chemicals Inc.
G-5555 8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met G5555;G 5555 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)- PAK1 inhibitor (g-5555) p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555 8-((trans-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 1648863-90-4 C25H25ClN6O3