G-5555
- CAS No.
- 1648863-90-4
- Chemical Name:
- G-5555
- Synonyms
- G-5555;G5555;G 5555;PAK1 inhibitor (g-5555);p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555;8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met;8-((trans-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-
- CBNumber:
- CB33126700
- Molecular Formula:
- C25H25ClN6O3
- Molecular Weight:
- 492.96
- MDL Number:
- MFCD28506227
- MOL File:
- 1648863-90-4.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
G-5555 price More Price(26)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML3237 | G-5555 ≥98% (HPLC) | 1648863-90-4 | 5MG | $102 | 2023-06-20 | Buy |
Sigma-Aldrich | SML3237 | G-5555 ≥98% (HPLC) | 1648863-90-4 | 25MG | $409 | 2023-06-20 | Buy |
Cayman Chemical | 21469 | G-5555 ≥98% | 1648863-90-4 | 500μg | $44 | 2024-03-01 | Buy |
Cayman Chemical | 21469 | G-5555 ≥98% | 1648863-90-4 | 1mg | $79 | 2024-03-01 | Buy |
Cayman Chemical | 21469 | G-5555 ≥98% | 1648863-90-4 | 5mg | $330 | 2024-03-01 | Buy |
G-5555 Chemical Properties,Uses,Production
Description
G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50 values ranging from 9 to 52 nM. G-5555 inhibits phosphorylation of MEK, a downstream target of PAK1, in EBC1 cells (IC50 = 69 nM). G-5555 (10, 20, and 30 mg/kg) dose-dependently reduces phosphorylation of MEK in tumors from an H292 non-small cell lung cancer (NSCLC) mouse xenograft model. G-5555 inhibits hERG channels less than 50% at a concentration of 10 μM, indicating the potential for a low risk of QT interval prolongation and potentially fatal arrhythmias.
Uses
G 5555 is a high affinity group 1 p21-activated kinases (PAK) inhibitor.
storage
Store at -20°C
G-5555 Preparation Products And Raw materials
Raw materials
Preparation Products
G-5555 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Heze Development Zone chuangli Chemical Co., Ltd. | +86-530-529 6766,+86-15666160102 15666160102 | info@chuangli-chem.com | China | 894 | 55 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |