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G-5555

G-5555 Structure
G-5555 structure
CAS No.
1648863-90-4
Chemical Name:
G-5555
Synonyms
G-5555;G5555;G 5555;PAK1 inhibitor (g-5555);p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555;8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met;8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-
CBNumber:
CB33126700
Molecular Formula:
C25H25ClN6O3
Molecular Weight:
492.96
MDL Number:
MFCD28506227
MOL File:
1648863-90-4.mol
Last updated:2024-07-02 08:55:06
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G-5555 Properties

Boiling point 684.6±65.0 °C(Predicted)
Density 1.363±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form A crystalline solid
pka 6.86±0.40(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

G-5555 price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3237 G-5555 ≥98% (HPLC) 1648863-90-4 5MG $102 2023-06-20 Buy
Sigma-Aldrich SML3237 G-5555 ≥98% (HPLC) 1648863-90-4 25MG $409 2023-06-20 Buy
Cayman Chemical 21469 G-5555 ≥98% 1648863-90-4 500μg $44 2024-03-01 Buy
Cayman Chemical 21469 G-5555 ≥98% 1648863-90-4 1mg $79 2024-03-01 Buy
Cayman Chemical 21469 G-5555 ≥98% 1648863-90-4 5mg $330 2024-03-01 Buy
Product number Packaging Price Buy
SML3237 5MG $102 Buy
SML3237 25MG $409 Buy
21469 500μg $44 Buy
21469 1mg $79 Buy
21469 5mg $330 Buy

G-5555 Chemical Properties,Uses,Production

Description

G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50 values ranging from 9 to 52 nM. G-5555 inhibits phosphorylation of MEK, a downstream target of PAK1, in EBC1 cells (IC50 = 69 nM). G-5555 (10, 20, and 30 mg/kg) dose-dependently reduces phosphorylation of MEK in tumors from an H292 non-small cell lung cancer (NSCLC) mouse xenograft model. G-5555 inhibits hERG channels less than 50% at a concentration of 10 μM, indicating the potential for a low risk of QT interval prolongation and potentially fatal arrhythmias.

Uses

G 5555 is a high affinity group 1 p21-activated kinases (PAK) inhibitor.

storage

Store at -20°C

G-5555 Preparation Products And Raw materials

Raw materials

Preparation Products

G-5555 Suppliers

Global( 26)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
Musechem +1-800-259-7612 info@musechem.com United States 4662 60
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Shanghai Zeye Biotechnology Co., Ltd. 021-61998551 13122364865 sale1@shzysw.net China 9771 58
Absin Bioscience Inc. 021-38015121 15000105423 chenjw@absin.cn China 24734 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10011 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
Musechem 60
DC Chemicals 58
Shanghai Zeye Biotechnology Co., Ltd. 58
Absin Bioscience Inc. 58
cjbscvictory 58
G-5555 8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met G5555;G 5555 8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)- PAK1 inhibitor (g-5555) p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555 1648863-90-4 C25H25ClN6O3