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ChemicalBook >> CAS DataBase List >> G-5555

G-5555

G-5555 price.
  • $44 - $2232
  • Product name: G-5555
  • CAS: 1648863-90-4
  • MF: C25H25ClN6O3
  • MW: 492.96
  • EINECS:
  • MDL Number:MFCD28506227
  • Synonyms:G-5555;8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met;G5555;G 5555;8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-;PAK1 inhibitor (g-5555);p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555
Price26 Properties Safety Information Description
26 prices
Selected condition：
Brand
  • AK Scientific
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 10
  • 1mg
  • 500μg
  • 50
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number9602EB
  • Product description8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one
  • Packaging1mg
  • Price$174
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number9602EB
  • Product description8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one
  • Packaging5mg
  • Price$452
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number9602EB
  • Product description8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one
  • Packaging10mg
  • Price$726
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611447
  • Product descriptionG-5555
  • Packaging5mg
  • Price$569.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611447
  • Product descriptionG-5555
  • Packaging10mg
  • Price$615.4
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611447
  • Product descriptionG-5555
  • Packaging50mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21469
  • Product descriptionG-5555 ≥98%
  • Packaging500μg
  • Price$44
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21469
  • Product descriptionG-5555 ≥98%
  • Packaging1mg
  • Price$79
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21469
  • Product descriptionG-5555 ≥98%
  • Packaging5mg
  • Price$330
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21469
  • Product descriptionG-5555 ≥98%
  • Packaging10mg
  • Price$614
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5608
  • Product descriptionG-5555 99.18%
  • Packaging1mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5608
  • Product descriptionG-5555 99.18%
  • Packaging5mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5608
  • Product descriptionG-5555 99.18%
  • Packaging10mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5608
  • Product descriptionG-5555 99.18%
  • Packaging25mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5608
  • Product descriptionG-5555 99.18%
  • Packaging50mg
  • Price$640
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5608
  • Product descriptionG-5555 99.18%
  • Packaging100mg
  • Price$1100
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9602EB 8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one 1mg $174 2021-12-16 Buy
AK Scientific 9602EB 8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one 5mg $452 2021-12-16 Buy
AK Scientific 9602EB 8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one 10mg $726 2021-12-16 Buy
Biorbyt Ltd orb611447 G-5555 5mg $569.5 2021-12-16 Buy
Biorbyt Ltd orb611447 G-5555 10mg $615.4 2021-12-16 Buy
Biorbyt Ltd orb611447 G-5555 50mg $1802 2021-12-16 Buy
Cayman Chemical 21469 G-5555 ≥98% 500μg $44 2024-03-01 Buy
Cayman Chemical 21469 G-5555 ≥98% 1mg $79 2024-03-01 Buy
Cayman Chemical 21469 G-5555 ≥98% 5mg $330 2024-03-01 Buy
Cayman Chemical 21469 G-5555 ≥98% 10mg $614 2024-03-01 Buy
ChemScene CS-5608 G-5555 99.18% 1mg $70 2021-12-16 Buy
ChemScene CS-5608 G-5555 99.18% 5mg $110 2021-12-16 Buy
ChemScene CS-5608 G-5555 99.18% 10mg $160 2021-12-16 Buy
ChemScene CS-5608 G-5555 99.18% 25mg $360 2021-12-16 Buy
ChemScene CS-5608 G-5555 99.18% 50mg $640 2021-12-16 Buy
ChemScene CS-5608 G-5555 99.18% 100mg $1100 2021-12-16 Buy
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Properties

Boiling point :684.6±65.0 °C(Predicted)
Density :1.363±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form :A crystalline solid
pka :6.86±0.40(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50 values ranging from 9 to 52 nM. G-5555 inhibits phosphorylation of MEK, a downstream target of PAK1, in EBC1 cells (IC50 = 69 nM). G-5555 (10, 20, and 30 mg/kg) dose-dependently reduces phosphorylation of MEK in tumors from an H292 non-small cell lung cancer (NSCLC) mouse xenograft model. G-5555 inhibits hERG channels less than 50% at a concentration of 10 μM, indicating the potential for a low risk of QT interval prolongation and potentially fatal arrhythmias.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Hangzhou MolCore BioPharmatech Co.,Ltd.
Aladdin Scientific
Amadis Chemical Company Limited Haoyuan Chemexpress Co., Ltd. Musechem DC Chemicals Shanghai Zeye Biotechnology Co., Ltd. Absin Bioscience Inc. cjbscvictory