7BIO
- CAS No.
- 916440-85-2
- Chemical Name:
- 7BIO
- Synonyms
- 7BIO;7BIO - CAS 916440-85-2 - Calbiochem;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3
- CBNumber:
- CB33136738
- Molecular Formula:
- C16H10BrN3O2
- Molecular Weight:
- 356.17
- MDL Number:
- MFCD28898970
- MOL File:
- 916440-85-2.mol
7BIO price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19619 | 7BIO ≥99% | 916440-85-2 | 10mg | $157 | 2024-03-01 | Buy |
| Cayman Chemical | 19619 | 7BIO ≥99% | 916440-85-2 | 50mg | $623 | 2024-03-01 | Buy |
| TRC | B591703 | 7BIO | 916440-85-2 | 25mg | $420 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0008614 | 7BIO 95.00% | 916440-85-2 | 5MG | $500.03 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-MR-C0020-M050 | 7BIO ≥99%(NMR) | 916440-85-2 | 50mg | $520 | 2021-12-16 | Buy |
7BIO Chemical Properties,Uses,Production
Description
7BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Instead, 7BIO inhibits FLT3 (IC50 = 0.34 μM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 μM, respectively). It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 μM, respectively.
Uses
7BIO is a caspase independent nonapoptotic cell death inducer.
storage
+4°C
References
[1] ribas j, bettayeb k, ferandin y, et al. 7-bromoindirubin-3′-oxime induces caspase-independent cell death[j]. oncogene, 2006, 25(47): 6304-6318.
[2] myrianthopoulos v, kritsanida m, gaboriaud-kolar n, et al. novel inverse binding mode of indirubin derivatives yields improved selectivity for dyrk kinases[j]. acs medicinal chemistry letters, 2012, 4(1): 22-26.
[3] myrianthopoulos v, magiatis p, ferandin y, et al. an integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases b and c by a series of 7-substituted indirubins[j]. journal of medicinal chemistry, 2007, 50(17): 4027-4037.
7BIO Preparation Products And Raw materials
Raw materials
Preparation Products
7BIO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3730 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 23963 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7980 | 58 |