7BIO
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- $157 - $791
- Product name: 7BIO
- CAS: 916440-85-2
- MF: C16H10BrN3O2
- MW: 356.17
- EINECS:
- MDL Number:MFCD28898970
- Synonyms:7BIO;7BIO - CAS 916440-85-2 - Calbiochem;2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
9 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- TRC
Package
- 5MG
- 10mg
- 25mg
- 50mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0020-M050
- Product description7BIO ≥99%(NMR)
- Packaging50mg
- Price$520
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number0492EM
- Product description7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one
- Packaging10mg
- Price$272
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number0492EM
- Product description7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one
- Packaging50mg
- Price$791
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0008614
- Product description7BIO 95.00%
- Packaging5MG
- Price$500.03
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5685
- Product description7BIO
- Packaging50mg
- Price$692
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC5685
- Product description7BIO
- Packaging10mg
- Price$173
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19619
- Product description7BIO ≥99%
- Packaging10mg
- Price$157
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19619
- Product description7BIO ≥99%
- Packaging50mg
- Price$623
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberB591703
- Product description7BIO
- Packaging25mg
- Price$420
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-MR-C0020-M050 | 7BIO ≥99%(NMR) | 50mg | $520 | 2021-12-16 | Buy |
| AK Scientific | 0492EM | 7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one | 10mg | $272 | 2021-12-16 | Buy |
| AK Scientific | 0492EM | 7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one | 50mg | $791 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0008614 | 7BIO 95.00% | 5MG | $500.03 | 2021-12-16 | Buy |
| ApexBio Technology | C5685 | 7BIO | 50mg | $692 | 2021-12-16 | Buy |
| ApexBio Technology | C5685 | 7BIO | 10mg | $173 | 2021-12-16 | Buy |
| Cayman Chemical | 19619 | 7BIO ≥99% | 10mg | $157 | 2024-03-01 | Buy |
| Cayman Chemical | 19619 | 7BIO ≥99% | 50mg | $623 | 2024-03-01 | Buy |
| TRC | B591703 | 7BIO | 25mg | $420 | 2021-12-16 | Buy |
Properties
storage temp. :+2C to +8C
solubility :Soluble in ethanol;DMSO
form :Deep black-red solid
color :Dark red
solubility :Soluble in ethanol;DMSO
form :Deep black-red solid
color :Dark red
Safety Information
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Description
7BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Instead, 7BIO inhibits FLT3 (IC50 = 0.34 μM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 μM, respectively). It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 μM, respectively.Suppliers and manufacturers
TargetMol Chemicals Inc.
Aladdin Scientific
BOC Sciences
Shanghai EFE Biological Technology Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
MedBioPharmaceutical Technology Inc
Bide Pharmatech Ltd.
TargetMol Chemicals Inc.
Suzhou Zhixin Biotechnology Co., Ltd.