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(R)-Butaprost, free acid

(R)-Butaprost, free acid Structure
(R)-Butaprost, free acid structure
CAS No.
215168-33-5
Chemical Name:
(R)-Butaprost, free acid
Synonyms
PAYNQYXOKJDXAV-NMXQQJQMSA-N;Cyclopentaneheptanoic acid,3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-butenyl]-5-oxo-,(1R,2R,3R)-;Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, (1R,2R,3R)-
CBNumber:
CB33136763
Molecular Formula:
C23H38O5
Molecular Weight:
394.54
MDL Number:
MOL File:
215168-33-5.mol
Last updated:2023-06-08 09:03:08
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(R)-Butaprost, free acid Properties

Boiling point 565.7±50.0 °C(Predicted)
Density 1.145±0.06 g/cm3(Predicted)
solubility DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .1 mg/ml
pka 4.77±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319-H336
Precautionary statements  P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501
NFPA 704
3
2 0

(R)-Butaprost, free acid price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10006045 (R)-Butaprost (free acid) ≥98% 215168-33-5 500μg $86 2024-03-01 Buy
Cayman Chemical 10006045 (R)-Butaprost (free acid) ≥98% 215168-33-5 1mg $161 2024-03-01 Buy
Cayman Chemical 10006045 (R)-Butaprost (free acid) ≥98% 215168-33-5 5mg $671 2024-03-01 Buy
Cayman Chemical 10006045 (R)-Butaprost (free acid) ≥98% 215168-33-5 10mg $1172 2024-03-01 Buy
Product number Packaging Price Buy
10006045 500μg $86 Buy
10006045 1mg $161 Buy
10006045 5mg $671 Buy
10006045 10mg $1172 Buy

(R)-Butaprost, free acid Chemical Properties,Uses,Production

Description

Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Serious confusion as to the structure of butaprost was generated by Gardiner in 1986, when he reported that the epimer of butaprost showing this selective activity was the C-16 (R)-epimer (See reference 2 and NOTE). In order to increase the binding affinity of (R)-butaprost for prostanoid receptors, we removed the methyl ester of (R)-butaprost and re-established the natural C-1 carboxylic acid. Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. The pharmacology of (R)-butaprost has not been carefully studied, but it is generally considered to be the less active C-16 epimer. (NOTE: In the Gardiner paper in the 1986 British Journal of Pharmacology, butaprost appears on page 46 where it is given the name TR 4979. The structure as drawn is incorrect, in that the author was using and referring to the more active C-16 epimer, which is actually 16(S). The structure on page 46 shows the structure as 16(R). It was not until the late 1990’s that careful studies both in the US and Japan correctly identified the actual configuration of C-16 in the compound called butaprost is 16(S).)

Definition

ChEBI: (r)-butaprost (free acid) is a prostanoid.

(R)-Butaprost, free acid Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-Butaprost, free acid Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 market@aladdin-e.com China 25013 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9707 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Haohong Scientific Co., Ltd. 400-400-8210725 malulu@leyan.com China 39990 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28091 58
Supplier Advantage
Aladdin Scientific 		58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58
Shanghai Haohong Scientific Co., Ltd. 58
TargetMol Chemicals Inc. 58
PAYNQYXOKJDXAV-NMXQQJQMSA-N Cyclopentaneheptanoic acid, 3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-buten-1-yl]-5-oxo-, (1R,2R,3R)- Cyclopentaneheptanoic acid,3-hydroxy-2-[(1E,4R)-4-hydroxy-4-(1-propylcyclobutyl)-1-butenyl]-5-oxo-,(1R,2R,3R)- 215168-33-5