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CRANAD 28
- CAS No.
- 1623747-97-6
- Chemical Name:
- CRANAD 28
- Synonyms
- CRANAD 28;CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit;1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
- CBNumber:
- CB33152594
- Molecular Formula:
- C27H23BF2N4O2
- Molecular Weight:
- 484.3049264
- MDL Number:
- MFCD30719248
- MOL File:
- 1623747-97-6.mol
Last updated:2024-11-19 23:02:33
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P305+P351+P338-P332+P313-P362+P364-P337+P313 | |||||||||
| NFPA 704 |
|
CRANAD 28 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 1623747-97-6 | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 1623747-97-6 | 1mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 1623747-97-6 | 5mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 1623747-97-6 | 10mg | $426 | 2024-03-01 | Buy |
| AK Scientific | SYN5491 | CRANAD-28 | 1623747-97-6 | 50mg | $1268 | 2021-12-16 | Buy |
CRANAD 28 Chemical Properties,Uses,Production
Description
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
CRANAD 28 Preparation Products And Raw materials
Raw materials
Preparation Products
CRANAD 28 Suppliers
Global( 39)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-024-88590548 18341751992 | 757984502@qq.com | China | 891 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4512 | 55 | |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 0086-15250997978 | 1511893459@qq.com | China | 7850 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
CRANAD 28
4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron
4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole)
CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit
4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole)
1623747-97-6
C27H23BF2N4O2