CRANAD 28
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- $32 - $1268
- Product name: CRANAD 28
- CAS: 1623747-97-6
- MF: C27H23BF2N4O2
- MW: 484.3049264
- EINECS:
- MDL Number:MFCD30719248
- Synonyms:CRANAD 28;4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole;1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole)
5 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 50mg
- ManufacturerAK Scientific
- Product numberSYN5491
- Product descriptionCRANAD-28
- Packaging50mg
- Price$1268
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19816
- Product descriptionCRANAD 28 ≥98%
- Packaging500μg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19816
- Product descriptionCRANAD 28 ≥98%
- Packaging1mg
- Price$61
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19816
- Product descriptionCRANAD 28 ≥98%
- Packaging5mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19816
- Product descriptionCRANAD 28 ≥98%
- Packaging10mg
- Price$426
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5491 | CRANAD-28 | 50mg | $1268 | 2021-12-16 | Buy |
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 1mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 5mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 19816 | CRANAD 28 ≥98% | 10mg | $426 | 2024-03-01 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form :A crystalline solid
color :Orange to red
solubility :DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form :A crystalline solid
color :Orange to red
Safety Information
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Description
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.Suppliers and manufacturers
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