ADU-S100 ammonium salt
- CAS No.
- 1638750-96-5
- Chemical Name:
- ADU-S100 ammonium salt
- Synonyms
- MIW815 ammonium salt;ADU-S100 ammonium salt;ML RR-S2 CDA (ammonium salt);STING-INDUCER-1 AMMONIUM SALT;ML RR-S2 CDA ammonium salt(ADU-S100);Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2);inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
- CBNumber:
- CB33155065
- Molecular Formula:
- C20H27N11O10P2S2
- Molecular Weight:
- 707.57
- MDL Number:
- MOL File:
- 1638750-96-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
ADU-S100 ammonium salt price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 24106 | ML RR-S2 CDA (ammonium salt) ≥98% | 1638750-96-5 | 500μg | $778 | 2024-03-01 | Buy |
Cayman Chemical | 24106 | ML RR-S2 CDA (ammonium salt) ≥98% | 1638750-96-5 | 1mg | $1164 | 2024-03-01 | Buy |
Biorbyt Ltd | orb611556 | ML RR-S2 CDA ammonium salt >98% | 1638750-96-5 | 10mg | $1356.6 | 2021-12-16 | Buy |
ChemScene | CS-6093 | ADU-S100ammoniumsalt 99.44% | 1638750-96-5 | 25mg | $2400 | 2021-12-16 | Buy |
Biorbyt Ltd | orb611556 | ML RR-S2 CDA ammonium salt >98% | 1638750-96-5 | 25mg | $2541.5 | 2021-12-16 | Buy |
ADU-S100 ammonium salt Chemical Properties,Uses,Production
Description
ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2''5'' and 3''5'' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; ), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models.
ADU-S100 ammonium salt Preparation Products And Raw materials
Raw materials
Preparation Products
ADU-S100 ammonium salt Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5224 | 58 |
Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4287 | 55 | |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8017 | 62 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
Heze Development Zone chuangli Chemical Co., Ltd. | +86-530-529 6766,+86-15666160102 15666160102 | info@chuangli-chem.com | China | 878 | 55 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |