|
|
| | ADU-S100 ammonium salt Basic information |
| Product Name: | ADU-S100 ammonium salt | | Synonyms: | ML RR-S2 CDA (ammonium salt);Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2);ML RR-S2 CDA ammonium salt(ADU-S100);MIW815 ammonium salt;STING-INDUCER-1 AMMONIUM SALT;ADU-S100 ammonium salt;inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt | | CAS: | 1638750-96-5 | | MF: | C20H27N11O10P2S2 | | MW: | 707.57 | | EINECS: | | | Product Categories: | | | Mol File: | 1638750-96-5.mol |  |
| | ADU-S100 ammonium salt Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: 15 mg/ml; Water: 12.5 mg/ml | | form | A solid | | color | White to off-white |
| | ADU-S100 ammonium salt Usage And Synthesis |
| Description | ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2''5'' and 3''5'' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; ), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models. |
| | ADU-S100 ammonium salt Preparation Products And Raw materials |
|