ADU-S100铵盐
中文名称 | ADU-S100铵盐 |
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中文同义词 | ADU-S100铵盐;化合物 T10252L2;化合物ADU-S100 AMMONIUM SALT |
英文名称 | ADU-S100 ammonium salt |
英文同义词 | ML RR-S2 CDA (ammonium salt);Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2);ML RR-S2 CDA ammonium salt(ADU-S100);MIW815 ammonium salt;STING-INDUCER-1 AMMONIUM SALT;ADU-S100 ammonium salt;inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt |
CAS号 | 1638750-96-5 |
分子式 | C20H27N11O10P2S2 |
分子量 | 707.57 |
EINECS号 | |
相关类别 | 活性分子 |
Mol文件 | 1638750-96-5.mol |
结构式 |
ADU-S100铵盐 性质
储存条件 | Store at -20°C |
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溶解度 | DMSO:15mg/mL;水:12.5mg/mL |
形态 | 固体 |
颜色 | 白色至米白色 |
STING
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes. In contrast, the dithio, mixed-linkage cyclic dinucleotide (CDN) derivatives (ML RR-CDA, ML RR-S2 CDG, and ML RR-S2 cGAMP) potently activate all five hSTING alleles, including the refractory hSTING REF and hSTING Q alleles. ADU-S100 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ADU-S100 is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ADU-S100 induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ADU-S100 compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8 + T cell responses, and improves long-term survival to 50%.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-12885B | ADU-S100铵盐 ADU-S100 ammonium salt | 1638750-96-5 | 1mg | 3300元 |
2023/03/20 | HY-12885B | ADU-S100铵盐 ADU-S100 ammonium salt | 1638750-96-5 | 5 mg | 12000元 |