ChemicalBook >> CAS DataBase List >>IDH-889
IDH-889
- CAS No.
- 1429179-07-6
- Chemical Name:
- IDH-889
- Synonyms
- IDH889;IDH-889;IDH889, 10 mM in DMSO;IDH889;IDH-889;IDH 889;Inhibitor,inhibit,Isocitrate Dehydrogenase (IDH),IDH889,IDH 889,IDH-889;2-Oxazolidinone, 3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)-2-pyrimidinyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)-
- CBNumber:
- CB33354248
- Molecular Formula:
- C23H25FN6O2
- Molecular Weight:
- 436.48
- MDL Number:
- MOL File:
- 1429179-07-6.mol
Last updated:2024-11-19 23:02:33
IDH-889 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0044740 | IDH889 | 1429179-07-6 | 5mg | $300 | 2021-12-16 | Buy |
| ChemScene | CS-0044740 | IDH889 | 1429179-07-6 | 10mg | $500 | 2021-12-16 | Buy |
| ChemScene | CS-0044740 | IDH889 | 1429179-07-6 | 25mg | $850 | 2021-12-16 | Buy |
| ChemScene | CS-0044740 | IDH889 | 1429179-07-6 | 50mg | $1200 | 2021-12-16 | Buy |
| ChemScene | CS-0044740 | IDH889 | 1429179-07-6 | 100mg | $1800 | 2021-12-16 | Buy |
IDH-889 Chemical Properties,Uses,Production
Description
IDH889 is a potent and selective inhibitors of IDH1. IDH899 shows IDH (R132H) IC50 = 20 nM; Cell 2-HG IC50 = 14 nM. IDH889 demonstrates significantly improved plasma exposure in mice vs IDH662 (AUC 3.6 μM·h, Cmax 1.7 μM at 10 mg/kg; AUC 55.5 μM·h, Cmax 14.2 μM at 100 mg/kg). IDH889 also has excellent permeability and no efflux in the Caco-2 and human MDR1-MDCK cell lines, supporting the hypothesis that potent inhibition of mutant IDH1 function by binding at the allosteric binding site is compatible with brain penetration.
IDH-889 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 22)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai XinKai Chemical Technology Co., Ltd. | 021-58930698 15921516558 | zhangyichao84@126.com | China | 929 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4589 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9805 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 9987 | 58 |
IDH889
IDH-889
IDH889;IDH-889;IDH 889
Inhibitor,inhibit,Isocitrate Dehydrogenase (IDH),IDH889,IDH 889,IDH-889
2-Oxazolidinone, 3-[2-[[(1S)-1-[5-(4-fluoro-3-methylphenyl)-2-pyrimidinyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)-
IDH889, 10 mM in DMSO
1429179-07-6