N,N,N',N'-Tetramethylazodicarboxamide
- CAS No.
- 10465-78-8
- Chemical Name:
- N,N,N',N'-Tetramethylazodicarboxamide
- Synonyms
- TMAD;DIAMIDE;Tetramethylazodicarboxamide;N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide;(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea;(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea;Nsc143013;Diamide ,98%;Diamide, 98%, for synthesis;Azobis(N,N-dimethylformamide)
- CBNumber:
- CB3340747
- Molecular Formula:
- C6H12N4O2
- Molecular Weight:
- 172.19
- MDL Number:
- MFCD00008318
- MOL File:
- 10465-78-8.mol
Melting point | 112 °C |
---|---|
Boiling point | 220.4±23.0 °C(Predicted) |
Density | 1.13±0.1 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | soluble in Methanol |
form | crystalline |
pka | -0?+-.0.70(Predicted) |
color | yellow |
BRN | 1910409 |
InChI | InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+ |
InChIKey | VLSDXINSOMDCBK-BQYQJAHWSA-N |
SMILES | C(=O)(/N=N/C(=O)N(C)C)N(C)C |
CAS DataBase Reference | 10465-78-8(CAS DataBase Reference) |
FDA UNII | 86EQC90W32 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
RTECS | LQ1041000 |
F | 4.10 |
HS Code | 29270000 |
N,N,N',N'-Tetramethylazodicarboxamide price More Price(29)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | D3648 | Diamide | 10465-78-8 | 1g | $143 | 2024-03-01 | Buy |
Sigma-Aldrich | D3648 | Diamide | 10465-78-8 | 5g | $629 | 2024-03-01 | Buy |
TCI Chemical | A1458 | 1,1'-Azobis(N,N-dimethylformamide) >97.0%(T) | 10465-78-8 | 1g | $23 | 2024-03-01 | Buy |
TCI Chemical | A1458 | 1,1'-Azobis(N,N-dimethylformamide) >97.0%(T) | 10465-78-8 | 5g | $84 | 2024-03-01 | Buy |
Alfa Aesar | J64865 | 1,1'-Azobis(N,N-dimethylformamide), 95% | 10465-78-8 | 1g | $140 | 2024-03-01 | Buy |
N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties,Uses,Production
Description
N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.
References
N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133
Chemical Properties
Yellow crystals
Uses
Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.
Definition
ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.
Synthesis Reference(s)
The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007
N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Suzhou BEC Biological Technology Co., Ltd. | +undefined13771885869 | all@bek.com.cn | China | 62 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 19343 | 58 |
Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 |
View Lastest Price from N,N,N',N'-Tetramethylazodicarboxamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2019-07-06 | N,N,N',N'-Tetramethylazodicarboxamide
10465-78-8
|
US $1.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
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- N,N,N',N'-Tetramethylazodicarboxamide
10465-78-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co