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N,N,N',N'-Tetramethylazodicarboxamide

N,N,N',N'-Tetramethylazodicarboxamide structure

CAS No.: 10465-78-8

Chemical Name:: N,N,N',N'-Tetramethylazodicarboxamide

Synonyms: TMAD;DIAMIDE;Tetramethylazodicarboxamide;N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide;(3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea;(E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea;Nsc143013;Diamide ,98%;Diamide, 98%, for synthesis;Azobis(N,N-dimethylformamide)

CBNumber:: CB3340747

Molecular Formula:: C6H12N4O2

Molecular Weight:: 172.19

MDL Number:: MFCD00008318

MOL File:: 10465-78-8.mol

Last updated:2024-11-19 23:02:33

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N,N,N',N'-Tetramethylazodicarboxamide Properties

Melting point	112 °C
Boiling point	220.4±23.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	soluble in Methanol
form	crystalline
pka	-0?+-.0.70(Predicted)
color	yellow
BRN	1910409
InChI	InChI=1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChIKey	VLSDXINSOMDCBK-BQYQJAHWSA-N
SMILES	C(=O)(/N=N/C(=O)N(C)C)N(C)C
CAS DataBase Reference	10465-78-8(CAS DataBase Reference)
FDA UNII	86EQC90W32

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
Safety Statements	22-24/25
WGK Germany	3
RTECS	LQ1041000
F	4.10
HS Code	29270000

N,N,N',N'-Tetramethylazodicarboxamide price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	D3648	Diamide	10465-78-8	1g	$143	2024-03-01	Buy
Sigma-Aldrich	D3648	Diamide	10465-78-8	5g	$629	2024-03-01	Buy
TCI Chemical	A1458	1,1'-Azobis(N,N-dimethylformamide) >97.0%(T)	10465-78-8	1g	$23	2024-03-01	Buy
TCI Chemical	A1458	1,1'-Azobis(N,N-dimethylformamide) >97.0%(T)	10465-78-8	5g	$84	2024-03-01	Buy
Alfa Aesar	J64865	1,1'-Azobis(N,N-dimethylformamide), 95%	10465-78-8	1g	$140	2024-03-01	Buy

Product number	Packaging	Price	Buy
D3648	1g	$143	Buy
D3648	5g	$629	Buy
A1458	1g	$23	Buy
A1458	5g	$84	Buy
J64865	1g	$140	Buy

N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties,Uses,Production

Description

N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.

References

N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133

Chemical Properties

Yellow crystals

Uses

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Definition

ChEBI: 1,1'-azobis(N,N-dimethylformamide) is a monoazo compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 38, p. 1652, 1973 DOI: 10.1021/jo00949a007

N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials

Raw materials

Silver oxide Triethylamine Dimethylcarbamoyl chloride Dichloromethane HYDRAZINE

Preparation Products

1-amino-9,10-dihydro-9,10-dioxoanthracene-2-carbaldehyde 2-[(1-amino-9,10-dihydro-9,10-dioxo-2-anthryl)methylene]hydrazone 1H-Indazole-3-diazonium, 6-chloro-

N,N,N',N'-Tetramethylazodicarboxamide Suppliers

Global( 197)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou BEC Biological Technology Co., Ltd.	+undefined13771885869	all@bek.com.cn	China	62	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	17322	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18777	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Changzhou Carman Chemical Co., Ltd.	15061933924		CHINA	514	58

Supplier	Advantage
Suzhou BEC Biological Technology Co., Ltd.	58
Accela ChemBio Inc.	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Changzhou Carman Chemical Co., Ltd.	58

View Lastest Price from N,N,N',N'-Tetramethylazodicarboxamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Diamide 10465-78-8	US $50.00-128.00 / mg		99.88%	10g	TargetMol Chemicals Inc.
	2019-07-06	N,N,N',N'-Tetramethylazodicarboxamide 10465-78-8	US $1.00 / KG	1KG	99%	1ton	Career Henan Chemical Co

Diamide
10465-78-8
US $50.00-128.00 / mg
99.88%
TargetMol Chemicals Inc.

N,N,N',N'-Tetramethylazodicarboxamide
10465-78-8
US $1.00 / KG
99%
Career Henan Chemical Co

N,N,N',N'-Tetramethylazodicarboxamide Spectrum

N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)MS N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)¹HNMR N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)IR1 N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)IR2 N,N,N',N'-Tetramethylazodicarboxamide(10465-78-8)Raman

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1,1-DIMETHYLUREA Formamide N,N,N',N'-Tetramethylazodicarboxamide

1of4

Tetramethylazodicarboxamide(TMAD) 1,1μ-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide), Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide Azodicarboxylic acid bis(dimethylamide), diamide, Diamide, Diazinedicarboxylic acid bis(N,N-dimethylamide), N,N,Nμ,Nμ-Tetramethylazodicarboxamide 1,1′-Azobis(N,N-dimethylformamide), Azodicarboxylic acid bis(dimethylamide) Diazenedicarboxylic acid bis(N,N-dimethylamide) Formamide, 1,1'-azobis[N,N-dimethyl- AZODICARBOXYLIC ACID BIS[DIMETHYLAMIDE] DIAZINE-DICARBOXYLIC ACID BIS[N,N-DIMETHYLAMIDE] 1,1'-AZOBIS(N,N'-DIMETHYLFORMAMIDE) 1,1'-AZOBIS(N,N-DIMETHYLFORMAMIDE) N,N,N',N'-TETRAMETHYLAZODICARBAMIDE N,N,N',N'-TETRAMETHYLAZODICARBOXAMIDE 1,1’-azobis(n,n-dimethyl-formamid n,n,n’,n’-tetramethylazoformamide Diamide N,N,N',N'-Tetramethylazodicarboxamide Azodicarboxylic acid bis(dimethylamide), diamide TMAD N,N,N',N'-tetramethylazodicarboxamide 1,1'-Azobis(N,N-dimethylformamide)≥ 98%(Titration) N,N,N',N'-Tetramethylazobisformamide Nsc143013 N,N,N',N'-Tetramethylazodicarboxamide(TMAD) Diamide ,98% 1-[(diMethylcarbaMoyl)iMino]-3,3-diMethylurea tetramethyl-diazenedicarboxamid tetramethyldiazenedicarboxamide 1,1-Azobis(N,N-dimethylforamide) 3-(N,N-dimethylcarbamoylimido)-1,1-dimethylurea Diamide 1,1-Azobis(N,N-dimethylformamide) blowing (and foaming) agent AC 3-(Dimethylcarbamoylimino)-1,1-dimethylurea Diazenedicarboxamide, tetramethyl- Azobis(N,N-dimethylformamide) N,N,N',N'-Tetramethyldiazene-1,2-dicarboxamide N,N,N',N'-Tetramethyldiazenedicarboxamide 1,1'-Azobis(N,N-dimethylformamide),98% 1,1'-Azobis(N,N-dimethylformamide) > Diamide, 98%, for synthesis 1,2-Diazenedicarboxamide, N1,N1,N2,N2-tetramethyl- N,N,N',N'-Tetramethylazodicarboxamide ISO 9001：2015 REACH TIANFU-CHEM CAS:10465-78-8 N,N,N',N'-Tetramethylazodicarboxamide (3E)-3-(dimethylcarbamoylimino)-1,1-dimethyl-urea DIAMIDE N1,N1,N2,N2-Tetramethyldiazene-1,2-dicarboxamide Tetramethylazodicarboxamide TMAD (E)-1-[(dimethylcarbamoyl)imino]-3,3-dimethylurea (E)-N1,N1,N2,N2-tetramethyldiazene-1,2-dicarboxamide N,N,N',N'-Tetramethylazodicarboxamide TMADN,N,N',N'-tetramethylazodicarboxamide N,N,N’,N’-Tetramethylazodicarboxamide(TMAD) 10465-78-8 CH32NCONNCONCH32 Amides BioChemical Building Blocks Biochemicals and Reagents Carbonyl Compounds Glyceraldehyde 3-Phosphate Dehydrogenase from a green algae