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2'-Fluoro-2'-deoxyuridine

2'-Fluoro-2'-deoxyuridine structure

CAS No.: 784-71-4

Chemical Name:: 2'-Fluoro-2'-deoxyuridine

Synonyms: 2'-FU;2-FdU;2'-FUDR;2'-F-2'-dU;Fioluridine;2'-FLUORO-D-URIDINE;2'-Fluoro-2'-deoxyur;2'-F-2'-deoxyuridine;2'-F-2'-deoxyuridine;2 '- Fluorodeoxyuridine

CBNumber:: CB3358175

Molecular Formula:: C9H11FN2O5

Molecular Weight:: 246.19

MDL Number:: MFCD01317293

MOL File:: 784-71-4.mol

MSDS File:: SDS

Last updated:2024-11-20 11:41:24

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2'-Fluoro-2'-deoxyuridine Properties

Melting point	147.0 to 153.0 °C
Density	1.63±0.1 g/cm3(Predicted)
refractive index	53 ° (C=0.3, H2O)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in methanol.
form	Powder
pka	9.39±0.10(Predicted)
color	White to Off-white
optical activity	α20/D +53°±3°, c = 0.3 in water
Water Solubility	soluble in water
InChI	InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
InChIKey	UIYWFOZZIZEEKJ-XVFCMESISA-N
SMILES	OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](F)[C@@H]1O
CAS DataBase Reference	784-71-4(CAS DataBase Reference)
FDA UNII	Y2YC903QW8

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Warning
Hazard statements	H315-H319-H335-H341b
Precautionary statements	P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c
Hazard Codes	Xn
Risk Statements	20/21/22-40
Safety Statements	22-36/37/39
HS Code	29389090

2'-Fluoro-2'-deoxyuridine price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D3615	2'-Deoxy-2'-fluorouridine >97.0%(HPLC)	784-71-4	1g	$31	2024-03-01	Buy
TCI Chemical	D3615	2'-Deoxy-2'-fluorouridine >97.0%(HPLC)	784-71-4	5g	$121	2024-03-01	Buy
Alfa Aesar	J65948	2'-Fluoro-2'-deoxyuridine, 97%	784-71-4	1g	$28.65	2024-03-01	Buy
Alfa Aesar	J65948	2'-Fluoro-2'-deoxyuridine, 97%	784-71-4	5g	$104.65	2024-03-01	Buy
Alfa Aesar	J65948	2'-Fluoro-2'-deoxyuridine, 97%	784-71-4	25g	$405.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
D3615	1g	$31	Buy
D3615	5g	$121	Buy
J65948	1g	$28.65	Buy
J65948	5g	$104.65	Buy
J65948	25g	$405.65	Buy

2'-Fluoro-2'-deoxyuridine Chemical Properties,Uses,Production

Description

2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.

Chemical Properties

White to almost white crystalline powder

Uses

A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Uses

2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.

Synthesis

Method for the synthesis of 2'-Fluoro-2'-deoxyuridine, comprising the following steps:
(1) Uridine, diphenyl carbonate was added in dimethylformamide, dissolved at elevated temperature, the solution was clarified, the catalyst sodium bicarbonate was added under the condition of maintaining temperature, the reaction was carried out at elevated temperature for the second time, the reaction was completed, the temperature was cooled down naturally to room temperature, stirred, filtered, and the cake was dried to obtain compound 2.
(2) Compound 2, anhydrous potassium fluoride, catalyst boron trifluoride ethyl ether dissolved in a solvent, temperature rise reaction, after the completion of the reaction, filtration and concentration, to obtain 2'-fluoro-2'-deoxyuridine.
However, the hydroxyl conversion rate of this method is low, 2'-fluoro-2'-deoxyuridine is an extremely viscous compound, and it cannot be cured and purified when the purity is not high, resulting in the need for the method to be purified by passing through a column at a later stage, and it cannot be used in a factory for continuous and scaled-up production.

2'-Fluoro-2'-deoxyuridine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-Fluoro-2'-deoxyuridine Suppliers

Global( 392)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ChemExpress	+86-021-58950125 +86-021-58950125;	info@chemexpress.com	China	781	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12834	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18150	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	+8615373025980	clara@hbshengyang.com	China	875	58
Hangzhou Verychem Science And Technology Co.Ltd	+86-86-57188162785 13606544505	lucy@verychem.com	China	1054	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	18751	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55

Supplier	Advantage
ChemExpress	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Shengyang Water Conservancy Engineering Co., Ltd.	58
Hangzhou Verychem Science And Technology Co.Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from 2'-Fluoro-2'-deoxyuridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-23	2'-Fluoro-2'-Deoxyuridine 784-71-4	US $150.00 / kg	1kg	99%	5ton	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-12-20	2'-Deoxy-2'-fluorouridine 784-71-4	US $0.00-0.00 / Kg	1Kg	98%	20Ton	Xinxiang Aurora Biotechnology Co.,Ltd.
2024-12-13	2'-Fluoro-2'-deoxyuridine 784-71-4	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD

2'-Fluoro-2'-Deoxyuridine
784-71-4
US $150.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

2'-Deoxy-2'-fluorouridine
784-71-4
US $0.00-0.00 / Kg
98%
Xinxiang Aurora Biotechnology Co.,Ltd.

2'-Fluoro-2'-deoxyuridine
784-71-4
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

2'-Fluoro-2'-deoxyuridine Spectrum

2'-Fluoro-2'-deoxyuridine(784-71-4)MS 2'-Fluoro-2'-deoxyuridine(784-71-4)IR1

784-71-4(2'-Fluoro-2'-deoxyuridine)Related Search:

Trifluridine 2'-Deoxyuridine Doxifluridine 2'-DEOXY-2'-FLUOROTHYMIDINE 5-Fluoro-2'-deoxyuridine 98%,(+)-5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2'-DEOXYURIDINE,5-FLUORO-2-DEOXYURIDINE,beta-5-fluoro-2’-deoxyuridin

uridine diphosphate glucose {= UDP-glucose} BrdU (Bromodeoxyuridine) Fluorine DMT-2′Fluoro-dU Phosphoramidite Uridine

2',2'-DIFLUORO-2'-DEOXYURIDINE 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-FLUORO-D-URIDINE 2'-FLUORODEOXYURIDINE-5,6-D2 2'-FLUORO-2'DEOXYURIDINE, [5'-3H] 2',2'-DIFLUORO-2'-DEOXYURIDINE 13C, 15N2

3',5'-DI-O-ACETYL-2'-DEOXY-2'-FLUOROURIDINE 5-FLUORO 2'-DEOXYURIDINE, [6-3H]-,5'-FLUORO-2'DEOXYURIDINE, [6-3H] 3',5'-DI-O-ACETYL-5-FLUORO-2'-DEOXYURIDINE

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1-(2'-FLUORO-2'-DESOXY-BETA-D-RIBOFURANOSYL)URACIL 2,4(1H,3H)-PYRIMIDINEDIONE, 1-(2-DEOXY-2-FLUORO-BETA-D-RIBOFURANOSYL) 2'-FLUORO-2'-DEOXYURIDINE 2'-FLUORO-2'-DESOXY-URIDINE 2'-DEOXY-2'-FLUOROURIDINE 2'-FLUORO-D-URIDINE 2'-FUDR 2'-FU 2'-DEOXY-2'-FLUOROURIDINE (2'-FLUORO-2'- DEOXYURIDINE, 2'-FU) 2'-Deoxy-2'-fluoro-D-uridine 2''-DEOXY-2''-FLUOROURIDINE (2''-FLUORO-2''- DEOXYURIDINE) URIDINE,2''-DEOXY-2''-FLUORO 2-FdU 2'-Fluoro-5'-O-DMT-2'-deoxyuridine 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione 1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone 2'-Fluoro-2'-deoxyur Fioluridine FN-011 2'-Fluoro-2'-deoxyuridine 2'-Deoxy-2'-fluorouridine≥ 97% (HPLC) 2'-Fluoro-2'-deoxyuridine 98% 2'-Deoxy-2'-fluorouridine, 98.0% Uridine Impurity 19 （2'-Fluoro-2'-deoxyuridine） 2'-Deoxy-2'-fluorouridine> 2'-F-2'-dU 2'-Fluoro-2'-deoxyuridine USP/EP/BP 2'-F-2'-deoxyuridine inhibit,2' Deoxy 2' fluorouridine,Inhibitor,antiinfluenza virus,influenza,Influenza Virus,intermediate,2'Deoxy2'fluorouridine 2 '- Fluorodeoxyuridine 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 2'-Fluoro-2'-Deoxyuridine (FdU) 2'-Deoxy-2'-fluorouridine 2'-Fluoro-2'-deoxyuridine 2'-F-2'-deoxyuridine 784-71-4 781-71-4 Bases & Related Reagents Intermediates & Fine Chemicals Nucleotides Pharmaceuticals API intermediates Biochemistry Nucleosides and their analogs Nucleosides, Nucleotides & Related Reagents Pyridines, Pyrimidines, Purines and Pteredines 784-71-4 Nucleosides Modified（deoxy）nucleoside Nucleosides-2'-F Nucleosides 1