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Caulophylline

Caulophylline structure

CAS No.: 486-86-2

Chemical Name:: Caulophylline

Synonyms: (1r)-l;Caulophyllin;Caulophylline;Methylcytisine;N-METHYLCYTISINE;12-Methylcytisine;12-methyl-cytisin;N-Methylcytisine-RM;Cytisine, 12-methyl-;METHYLCYTISINE, N-(P)

CBNumber:: CB3366194

Molecular Formula:: C12H16N2O

Molecular Weight:: 204.27

MDL Number:: MFCD00211091

MOL File:: 486-86-2.mol

MSDS File:: SDS

Last updated:2024-11-19 23:02:33

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Caulophylline Properties

Melting point	137-139oC
alpha	30D -224° (c = 1.05 in water)
Boiling point	342.77°C (rough estimate)
Density	1.0565 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	powder
pka	9.61±0.20(Predicted)
color	White to Off-White
EWG's Food Scores	1
FDA UNII	TT0MW69NCI
NIST Chemistry Reference	Caulophylline(486-86-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

P261-P271-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312

Hazard Codes

Risk Statements

WGK Germany

RTECS

HA4400000

Toxicity

LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod)

NFPA 704

	0
1		0

Caulophylline price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SMB00353	N-Methylcytisine ≥98% (HPLC)	486-86-2	5mg	$197	2024-03-01	Buy
Sigma-Aldrich	PHL83219	N-Methylcytisine phyproof? Reference Substance	486-86-2	10mg	$574	2024-03-01	Buy
Sigma-Aldrich	CDS010442	N-Methylcytisine AldrichCPR	486-86-2	25mg	$308	2023-06-20	Buy
Usbiological	M3398-60	N-Methylcytisine	486-86-2	25mg	$460	2021-12-16	Buy
TRC	M294680	N-Methylcytisine	486-86-2	100mg	$460	2021-12-16	Buy

Product number	Packaging	Price	Buy
SMB00353	5mg	$197	Buy
PHL83219	10mg	$574	Buy
CDS010442	25mg	$308	Buy
M3398-60	25mg	$460	Buy
M294680	100mg	$460	Buy

Caulophylline Chemical Properties,Uses,Production

Description

This base was first prepared synthetically by Partheil and subsequently discovered in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.) Richards. It is laevorotatory with [α]²⁰_D - 221 ° (H20) and furnishes the following crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide, m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p. 206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.

Chemical Properties

Colourless Needles

Uses

N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.

General Description

N-Methylcytisine is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh.

Hazard

Extremely toxic; cardiotoxic; poisonous.

Biochem/physiol Actions

N-Methylcytisine is toxic and binds selectively to nicotinic acetylcholine receptors in the CNS.

References

Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)

Caulophylline Preparation Products And Raw materials

Raw materials

Preparation Products

Caulophylline Suppliers

Global( 201)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Shanghai Standard Technology Co., Ltd.	58
Wuhan ChemNorm Biotech Co.,Ltd.	58

View Lastest Price from Caulophylline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	N-Methylcytisine 486-86-2	US $48.00-147.00 / mg		99.83%	10g	TargetMol Chemicals Inc.
2023-02-24	N-Methylcytisine 486-86-2	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2019-07-06	Caulophylline 486-86-2	US $1.00 / KG	1g	99%	100KG	Career Henan Chemical Co

N-Methylcytisine
486-86-2
US $48.00-147.00 / mg
99.83%
TargetMol Chemicals Inc.

N-Methylcytisine
486-86-2
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Caulophylline
486-86-2
US $1.00 / KG
99%
Career Henan Chemical Co

Caulophylline Spectrum

Caulophylline(486-86-2)¹HNMR

486-86-2(Caulophylline)Related Search:

1-Methylimidazole CYTISINE N-Methyl-2-pyrrolidone Sodium carboxymethyl cellulose N,N-Dimethylformamide

(-)-SPARTEINE 1-Methylpyrrolidine 2'H-Androst-2-eno[3,2-c]pyrazol-5'(1'H)-one, 17-hydroxy-17-(methyl-d3)-, (5α,17β)- (9CI) L-N-METHYLEPHEDRINE HYDROCHLORIDE Caulophylline hydriodide

(-)-2-[METHYLAMINO]-1-PHENYLPROPANE (-)-N-METHYLEPHEDRINE ANAGYRINE Caulophylline 3-(2-AMINO-ACETYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE

3-(2-AMINO-3-METHYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE AKOS 213-126 3-(2-AMINO-4-METHYLSULFANYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE

1of4

N-METHYLCYTISINE (1r)-l 1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)- 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R-cis)- 12-methyl-cytisin 12-Methylcytisine Caulophyllin Caulophylline Cytisine, 12-methyl- (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one (1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one (1R,5S)-3-Methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one [1R,(-)]-3-Methyl-1,2,3,4,5,6-hexahydro-1α,5α-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one METHYLCYTISINE, N-(P) N-Methylcytisine AldrichCPR Methylcytisine N-Methylcytisine hydrobromide N-Methylcytisine, 98%, from Sophora flavescens Aiton 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)- Caulophylline USP/EP/BP (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]... (1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one Caulophylline (N-Methylcytisine) N-Methylcytisine-RM 486-86-2 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). Miscellaneous Reagents standardized herbal extract