ChemicalBook >> CAS DataBase List >>4'-CHLOROACETANILIDE
4'-CHLOROACETANILIDE
- CAS No.
- 539-03-7
- Chemical Name:
- 4'-CHLOROACETANILIDE
- Synonyms
- NSC 444;NSC 40563;4-Chloroacetan;PARACETAMOL RC J;4-CHLORACETANILIDE;p-Chloroacetanilid;P-CHLOROACETANILIDE;4-CHLOROACETANILIDE;4'-CHLOROACETANILIDE;ACETAMINOPHENE IMP J
- CBNumber:
- CB3377826
- Molecular Formula:
- C8H8ClNO
- Molecular Weight:
- 169.61
- MDL Number:
- MFCD00000612
- MOL File:
- 539-03-7.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Melting point | 176-178 °C(lit.) |
|---|---|
| Boiling point | 333 °C |
| Density | 1,385 g/cm3 |
| refractive index | 1.5670 (estimate) |
| Flash point | 333°C |
| storage temp. | 2-8°C |
| solubility | dioxane: 50 mg/mL hot, clear |
| pka | 14.25±0.70(Predicted) |
| form | Crystalline Powder |
| color | White or grayish-beige |
| Water Solubility | Insoluble in water. |
| Merck | 14,2111 |
| BRN | 509638 |
| CAS DataBase Reference | 539-03-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 6I0LI34G5J |
| EPA Substance Registry System | 4-Chloroacetanilide (539-03-7) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AE1001000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29242990 | |||||||||
| Hazardous Substances Data | 539-03-7(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
4'-CHLOROACETANILIDE price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001945 | Paracetamol impurity J European Pharmacopoeia (EP) Reference Standard | 539-03-7 | Y0001945 | $152 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.41480 | 4-Chloroacetanilide for synthesis | 539-03-7 | 50g | $65.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.41480 | 4-Chloroacetanilide for synthesis | 539-03-7 | 250g | $299 | 2024-03-01 | Buy |
| Sigma-Aldrich | 158631 | 4′-Chloroacetanilide 97% | 539-03-7 | 5g | $43.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1003100 | Acetaminophen Related Compound J United States Pharmacopeia (USP) Reference Standard | 539-03-7 | 50mg | $1380 | 2024-03-01 | Buy |
4'-CHLOROACETANILIDE Chemical Properties,Uses,Production
Chemical Properties
white or greyish-beige crystalline powder
Uses
4'-Chloroacetanilide is used in pharmaceutical preparations, using PGC column. And also used in the synthesis of alprazolam.
Definition
ChEBI: Acetamide substituted on nitrogen by a para-chlorophenyl group.
Synthesis Reference(s)
Tetrahedron, 52, p. 8863, 1996 DOI: 10.1016/0040-4020(96)00433-4
General Description
4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.
Purification Methods
Crystallise the anilide from EtOH or aqueous EtOH. [Beilstein 12 IV 1178.]
4'-CHLOROACETANILIDE Preparation Products And Raw materials
Global( 371)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1227 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
View Lastest Price from 4'-CHLOROACETANILIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-23 | 4'-CHLOROACETANILIDE
539-03-7
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 4'-CHLOROACETANILIDE
539-03-7
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2025-03-21 | 4'-CHLOROACETANILIDE
539-03-7
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd |
-
- 4'-CHLOROACETANILIDE
539-03-7
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4'-CHLOROACETANILIDE
539-03-7
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4'-CHLOROACETANILIDE
539-03-7
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
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