ANTI-HIF-1ALPHA
- CAS No.
- Chemical Name:
- ANTI-HIF-1ALPHA
- Synonyms
- ANTI-HIF-1ALPHA;Anti-ARNT protein 2;ANTI-HIF-1ALPHA, HUMAN;ANTI-HIF-1ALPHA (C-TERM);ANTI-HIF-1ALPHA MOUSE MAB;MONOCLONAL ANTI-HIF-1ALPHA;ANTI-HYPOXIA-INDUCIBLE FACTOR-1ALPHA;Anti-HIF1A antibody produced in rabbit;Anti-ARNT2 antibody produced in rabbit;ANTI-HYPOXIA-INDUCIBLE FACTOR 1ALPHA, HUMAN
- CBNumber:
- CB3404863
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD01633488
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H412 |
| Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 |
| WGK Germany | - |
ANTI-HIF-1ALPHA price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB5200017 | Monoclonal Anti-HIF-1 α antibody produced in mouse clone ESEE122, 1?mg/mL, purified immunoglobulin | 100μG | $524 | 2024-03-01 | Buy | |
| Sigma-Aldrich | SAB2702132 | Anti-HIF1A antibody produced in rabbit | 100μL | $496 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA001056 | Anti-ARNT2 antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution | 100μL | $580 | 2024-03-01 | Buy | |
| Sigma-Aldrich | H6536 | Monoclonal Anti-HIF-1α antibody produced in mouse ~1?mg/mL, clone H1α67, purified immunoglobulin, buffered aqueous solution | 100μg | $601 | 2024-03-01 | Buy | |
| Sigma-Aldrich | HPA001056 | Anti-ARNT2 antibody produced in rabbit affinity isolated antibody, buffered aqueous glycerol solution | 25μL | $282 | 2023-06-20 | Buy |
ANTI-HIF-1ALPHA Chemical Properties,Uses,Production
Uses
Monoclonal anti-HIF-1α antibody (diluted 1: 500) can be used in immunofluorescence confocal microscopy. It can also be used in in immunoblotting, immunoprecipitation and immunohistochemistry.
Uses
Rabbit polyclonal anti-HIF1A antibody is used to tag hypoxia-inducible factor 1 α for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. It is used as a probe to determine the presence and roles of hypoxia-inducible factor 1 α in the structure and function of hypoxia-inducible factor 1.
General Description
The gene encoding HIF1A (hypoxia inducible factor 1 subunit α) is localized on human chromosome 14q23.2. It is part of the HIF-1 heterodimer complex and is modulated by oxygen.
Biochem/physiol Actions
Hypoxia-inducible factor-1(HIF1) plays an essential role in cellular and systemic homeostatic responses to hypoxia. During hypoxia, the two subunits of this factor undergo post-translational modifications which in turn promote transactivation. HIF-1α gene loss is associated with development of nonpapillary renal carcinomas. The encoded protein functions as a key regulator of the vascular endothelial growth factor (VEGF) under hypoxic response in human stromal cells in vitro. HIF-1α protein expression is often seen in invasive breast cancer. Experimental data demonstrates that downregulation of HIF-1α decreases tumorigenicity of MCF-7 (human breast adenocarcinoma cell line) cells and propose a promising combination of both anti-HIF-1 strategy and traditional chemotherapy to improve cancer treatment.
ANTI-HIF-1ALPHA Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-HIF-1ALPHA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
| Chemicon Internatinal, Inc. | -- | custserv@chemicon.com | United States | 4175 | 65 |
| ABR-Affinity BioReagents | -- | affinity@bioreagents.com | United States | 489 | 73 |
| Cayman Chemical Company | -- | cayman@caymanchem.com | United States | 6618 | 81 |
| Novus Biologicals, Inc. | -- | novus@novusbio.com | United States | 175 | 77 |
| BIOMOL INTERNATIONAL, LP | -- | info@biomol.com | United States | 1503 | 77 |
| Kamiya Biomedical Company | -- | ordering@kamiyabiomedical.com | United States | 736 | 72 |
| Alexis Corporation | -- | alexis-ch@alexis-corp.ch | Switzerland | 3599 | 74 |
| EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6529 | 66 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| Chemicon Internatinal, Inc. | 65 |
| ABR-Affinity BioReagents | 73 |
| Cayman Chemical Company | 81 |
| Novus Biologicals, Inc. | 77 |
| BIOMOL INTERNATIONAL, LP | 77 |
| Kamiya Biomedical Company | 72 |
| Alexis Corporation | 74 |
| EMD Biosciences, Inc. | 66 |