K-252C
- CAS No.
- 85753-43-1
- Chemical Name:
- K-252C
- Synonyms
- K-252C;Staurosporonine;Staurosporinone;STAUROSPORINE AGLYCONE;K-252c(Staurosporinone);Staurosporinone, K-252c;K252c, Ready Made Solution;Staurosporine Aglycone >99%;K-252c - CAS 85753-43-1 - Calbiochem;Staurosporinone, Staurosporine Aglycone
- CBNumber:
- CB3406463
- Molecular Formula:
- C20H13N3O
- Molecular Weight:
- 311.34
- MDL Number:
- MFCD00236435
- MOL File:
- 85753-43-1.mol
- MSDS File:
- SDS
| Melting point | >200°C (dec.) |
|---|---|
| storage temp. | −20°C |
| solubility | DMSO: 10 mg/mL, soluble |
| form | solid |
| color | Pale Brown to Light Brown |
| Water Solubility | Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water. |
| FDA UNII | HAJ5XS5HPF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| RIDADR | NA 1993 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
K-252C price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 420305 | K-252c | 85753-43-1 | 1mg | $289 | 2024-03-01 | Buy |
| Alfa Aesar | J63090 | K252c, 99% | 85753-43-1 | 5mg | $465 | 2021-12-16 | Buy |
| Alfa Aesar | J63090 | K252c, 99% | 85753-43-1 | 1mg | $104 | 2021-12-16 | Buy |
| Cayman Chemical | 13514 | K-252c ≥98% | 85753-43-1 | 1mg | $87 | 2024-03-01 | Buy |
| Cayman Chemical | 13514 | K-252c ≥98% | 85753-43-1 | 5mg | $341 | 2024-03-01 | Buy |
K-252C Chemical Properties,Uses,Production
Uses
Inhibits protein kinase C
Biological Activity
Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV).
storage
-20°C
References
1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819.
K-252C Preparation Products And Raw materials
Raw materials
Preparation Products
K-252C Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30240 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52925 | 58 |
| Aurisco Pharmaceutical (Tianjin) Inc. | 022-59885855 | liuyujie@aurisco.com | China | 96 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 10035 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |