Midostaurin | 120685-11-2

Midostaurin Properties

Melting point	235-260℃
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml), 100% ethanol (2.5 mg/ml), and DMF (20 mg/ml).
pka	14.19±0.70(Predicted)
form	Tan solid
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
FDA UNII	ID912S5VON
NCI Dictionary of Cancer Terms	midostaurin; N-benzoyl-staurosporine
NCI Drug Dictionary	midostaurin
ATC code	L01EX10

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS08

Signal word

Danger

Hazard statements

H360FD

Precautionary statements

P201-P202-P280-P308+P313-P405-P501

Hazard Codes

T

Risk Statements

36/37/38

HS Code

29329990

NFPA 704

	0
2		0

Midostaurin price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	539648	Staurosporine, N-Benzoyl A cell-permeable Staurosporine derivative that displays antitumor properties.	120685-11-2	1mg	$289	2024-03-01	Buy
Alfa Aesar	J62917	Midostaurin	120685-11-2	1mg	$119	2023-06-20	Buy
Alfa Aesar	J62917	Midostaurin	120685-11-2	5mg	$424	2023-06-20	Buy
Cayman Chemical	10459	PKC 412 ≥98%	120685-11-2	1mg	$28	2024-03-01	Buy
Cayman Chemical	10459	PKC 412 ≥98%	120685-11-2	5mg	$84	2024-03-01	Buy

Product number	Packaging	Price	Buy
539648	1mg	$289	Buy
J62917	1mg	$119	Buy
J62917	5mg	$424	Buy
10459	1mg	$28	Buy
10459	5mg	$84	Buy

Midostaurin Chemical Properties,Uses,Production

Binding Mode

The only available X-ray co-crystal structure of midostaurin is in complex with DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A)(Fig.1). Midostaurin is anchored to the hinge with two hydrogen bonds: the lactam NH with amide carbonyl of Glu239; and the lactam carbonyl with amide NH of Leu241 (Fig.2).
Figure 1. Co-crystal structure of midostaurin in complex with human DYRK1A (PDB ID: 4NCT). Figure 2. Summary of midostaurin–human DYRK1A interactions based on their co-crystal structure.

Description

PKC-412 (120685-11-2) is a broad spectrum kinase inhibitor. Inhibited kinases include, but are not limited to; PKA, PKC, S6 Kinase, KDR, PKC, Akt, EGFR, VEGFR, PDGFR, c-kit, and FLT-3. Acute myeloid leukemia related mutant forms of FLT-3 are also inhibited both in vitro and in vivo. PKC-412 has been demonstrated to induce apoptosis and shows broad antiproliferative activity in various tumor cell lines. Cell Permeable

Uses

Midostaurin is used as a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. Due to this act which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors. Midostaurin was shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

Definition

ChEBI: An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.

brand name

Rydapt

General Description

Class: receptor tyrosine kinase; Treatment: AML, SM; Other name: PKC-412, CGP41251; Elimination half-life = 20 h; Protein binding > 99%

Biological Activity

Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms ( α , β , γ ), PDFR β , VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

target

Primary targets: FLT3, KIT

storage

Store at -20°C

References

1) Odgerel et al. (2008) The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations; Oncogene, 27 3102 2) El Fitori et al. (2007) PKC 412 small-molecule tyrosine kinase inhibitor: single-compound therapy for pancreatic cancer; Cancer, 110 1457 3) Miyatake, et al. ( 2007) PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.macrophages; Biochem. Biophys. Res. Commun., 360 115 4) Bahlis et.al. (2005) N-Benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells; Leuk. Lymphoma, 46 899 5) Fabbro et al., (2000) PKC-412 – a protein kinase inhibitor with a broad therapeutic potential; Anticancer Drug Des., 15 17

Midostaurin Preparation Products And Raw materials

Raw materials

Preparation Products

Midostaurin Suppliers

Global( 234)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
shandong perfect biotechnology co.ltd	+86-53169958659 +86-13153181156	sales@sdperfect.com	China	294	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1001	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	997	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9028	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58

Supplier	Advantage
shandong perfect biotechnology co.ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
TopScience Biochemical	58

View Lastest Price from Midostaurin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-12-13	Midostaurin 120685-11-2	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-19	Midostaurin 120685-11-2	US $0.00 / g	1g	98% HPLC	1kg	shandong perfect biotechnology co.ltd
2024-11-18	Midostaurin 120685-11-2	US $47.00-128.00 / mg		99.56%	10g	TargetMol Chemicals Inc.

Midostaurin
120685-11-2
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Midostaurin
120685-11-2
US $0.00 / g
98% HPLC
shandong perfect biotechnology co.ltd

Midostaurin
120685-11-2
US $47.00-128.00 / mg
99.56%
TargetMol Chemicals Inc.

Midostaurin Spectrum

Midostaurin(120685-11-2)¹HNMR

120685-11-2(Midostaurin)Related Search:

CYCLOPAMINE Cantharidin Troglitazone ZM 447439 CGP52421

Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-hydroxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- 3 Hydroxy Midostaurin Epimer 2 (CGP52421 Epimer 2) 3 Hydroxy Midostaurin Epimer 1 (CGP52421 Epimer 1) Epothilone D Ibrutinib

CARBAZOL-9-YL-METHANOL 9-ISOPROPYLCARBAZOLE 11,12-Dihydroindolo[2,3-a]carbazole Midostaurin K-252C

1of3

CGP 41251MIDOSTAURIN(PKC412) N-((5S,6R,7R,9R)-6-Methoxy-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-Methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-MethylbenzaMide PKC-412, CGP-41251 Midostaurin (PKC412) PKC412 (Midostaurin) CGP 41231 N-Benzoylstaurosporine (Midostaurin) Benzoylstaurosporine midostaruin 4'-N-benzoylstaurosporine Midostaurin, Benzoylstaurosporine, 4'-N-Benzoylstaurosporine, CGP 41251 Benzamide, N-((9S,10R,11R,13R)-2,3,9,10,11,12-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-J)(1,7)benzodiazonin-11-yl)-N-methyl- Benzamide, N-(2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-1-oxo-8,12-epoxy-1H,8H-2,7B,12A-triazadibenzo(A,G)cyclonona(cde)trinden-10-yl)-N-methyl-, (8alpha,9beta,10beta,12alpha)- Benzoylstaurosporine Cgp 41 251 Cgp 41251 Cgp-41251 Midostaurin Midostaurin [inn] [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide PKC412 CGP 41231 CGP 41251 Midostaurin Benzoylstaurosporine Benzamide, N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl- Midostaurin USP/EP/BP Midaustorin N-((5S,6R,7R,9S)-6-Methoxy-5-methyl-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide PKC412(Midostaurin,CGP41231,CGP41251) PKC412 from Staurosporine QTH113 Staurosporine, N-Benzoyl MIDOSTAURIN; CGP-41251; PKC-412; PKC412;PKC 412 CS-730 MIDOSTAURIN (PKC412; CGP 41251) Midoridoline N-((5S,6R,7R,9R)-6-Methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide Midostaurin (Amorphous and Form II) N-((5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-5,6,7,8,9,14,15,16-octahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide PKC 412A PKC412A PKC-412A Midostaurin Impurity 120685-11-2 20685-11-2 C35H30N4O4 C325H30N4O4 antibiotic Pharmaceutical