4-BETA-HYDROXYCHOLESTEROL
- CAS No.
- 17320-10-4
- Chemical Name:
- 4-BETA-HYDROXYCHOLESTEROL
- Synonyms
- 4-Hydroxy Cholesterol;4--Hydroxy Cholestrol;cholest-5-ene-3,4-diol;4β-Hydroxy Cholesterol;Cholesterol Impurity 30;5-CHOLESTEN-3β, 4β-DIOL;4-BETA-HYDROXYCHOLESTEROL;4β-Hydroxycholesterol-[d4];4β-Hydroxycholesterol-[d5];2H4]-4β-Hydroxycholesterol
- CBNumber:
- CB3417069
- Molecular Formula:
- C27H46O2
- Molecular Weight:
- 402.65
- MDL Number:
- MFCD00201408
- MOL File:
- 17320-10-4.mol
| Melting point | 172-174°C |
|---|---|
| Boiling point | 500.2±30.0 °C(Predicted) |
| Density | 1.03±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 14.32±0.70(Predicted) |
| color | White to Pale Beige |
| FDA UNII | 3T705H20G7 |
4-BETA-HYDROXYCHOLESTEROL price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R208795 | CHOLEST-5-ENE-3-BETA,4-BETA-DIOL AldrichCPR | 17320-10-4 | 1MG | $29.8 | 2024-03-01 | Buy |
| Cayman Chemical | 19518 | 4β-hydroxy Cholesterol ≥98% | 17320-10-4 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19518 | 4β-hydroxy Cholesterol ≥98% | 17320-10-4 | 5mg | $77 | 2024-03-01 | Buy |
| Cayman Chemical | 19518 | 4β-hydroxy Cholesterol ≥98% | 17320-10-4 | 10mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 19518 | 4β-hydroxy Cholesterol ≥98% | 17320-10-4 | 25mg | $283 | 2024-03-01 | Buy |
4-BETA-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.
Definition
ChEBI: A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in he human circulation.
Biological Activity
4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].cytochome p450 3a4 (cyp3a4) and cyp3a5 are important drug-metabolizing enzymes that oxidize small foreign organic molecules, such as toxins or drugs, and remove them from the body. they exhibit a large variation in hepatic expression and biological activity between different individuals. patients treated with drugs known to be strong inducers of cyp3a4/5 have highly elevated levels of 4β-hydroxycholesterol in the circulation [1].4β-hydroxy cholesterol, an endogenous oxysterol found in human circulation, is formed from cholesterol by cytochrome p450 (cyp) 3a4 and cyp3a5. in 12 different occasions during a 3-month period, the cvs for 4β-hydroxycholesterol ranged from 4.8 to 13.2% with an average cv of 7.1% at an average concentration of 30.8 ng/ml. in 24 volunteers treated with rifampicin, a strong cyp3a4/5 inducer, 4β-hydroxycholesterol increased in a dose-dependent way, while the isomer 4α-hydroycholesterol was not influenced by rifampicin treatment. these results suggested that 4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].
References
[1]. diczfalusy u, kanebratt kp, bredberg e, et al. 4beta-hydroxycholesterol as an endogenous marker for cyp3a4/5 activity. stability and half-life of elimination after induction with rifampicin. br j clin pharmacol. 2009 jan;67(1):38-43.
4-BETA-HYDROXYCHOLESTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 18018 | 56 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8147 | 55 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4515 | 55 |