8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- CAS No.
- 129735-01-9
- Chemical Name:
- 8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
- Synonyms
- RP-8-CPT-CAMPS;RP-8-CPT-CAMPS SODIUM SALT;8-(4-CHLOROPHENYLTHIO)ADENOSINE-*3',5-CYCLIC MONOPH;8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER;Adenosine, 8-[(4-chlorophenyl)thio]-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate];8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT;8-(4-chlorophenylthio)adenosine-3’,5’-cyclicmonophosphorothioate,spisomer(sp-8-cpt-camps),sodi
- CBNumber:
- CB3431184
- Molecular Formula:
- C16H14ClN5NaO5PS2
- Molecular Weight:
- 509.86
- MDL Number:
- MFCD04113744
- MOL File:
- 129735-01-9.mol
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C0735 | 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt ≥99% (HPLC), solid | 129735-01-9 | 1VIAL | $884 | 2024-03-01 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| C0735 | 1VIAL | $884 | Buy |
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Chemical Properties,Uses,Production
Uses
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2].
Biological Activity
Lipophilic analog of the competitive inhibitor of protein kinase A (cyclic AMP antagonist).
References
[1] Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. PMID:2162349
[2] Roscioni SS, et, al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009 Sep 29;10(1):88. DOI:10.1186/1465-9921-10-88
[3] Chaisakul J, et, al. In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse". Toxicol Lett. 2012 Sep 3;213(2):243-8. DOI:10.1016/j.toxlet.2012.06.015
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
8-(4-CHLOROPHENYLTHIO)ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| BOC Sciences | 16314854226 | inquiry@bocsci.com | United States | 9713 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19820 | 58 |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | Enzoname@qq.com | China | 177174 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 292394 | 58 |
| Santa Cruz Biotechnology Inc | 60936350 | scbt@scbt.com | China | 222068 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| Aladdin Scientific | 58 |
| BOC Sciences | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Enzo Biochem Inc | 58 |
| Merck KGaA | 58 |
| Santa Cruz Biotechnology Inc | 58 |