RO-52 (SSA) HUMAN
- CAS No.
- Chemical Name:
- RO-52 (SSA) HUMAN
- Synonyms
- RO-52 (SSA) HUMAN
- CBNumber:
- CB3474864
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03458409
- MOL File:
- Mol file
RO-52 (SSA) HUMAN price More Price(1)
RO-52 (SSA) HUMAN Chemical Properties,Uses,Production
Uses
RO-52 (SSA) human has been used:
- as a component of the autoantigen array
- to immobilise protein on the self-assembly monolayer
- in enzyme-linked immunosorbent assays (ELISAs)
General Description
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5. It is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis. Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Biochem/physiol Actions
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.
RO-52 (SSA) HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
RO-52 (SSA) HUMAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |