Poly(hexamethylenebiguanide)hydrochloride
- CAS No.
- 32289-58-0
- Chemical Name:
- Poly(hexamethylenebiguanide)hydrochloride
- Synonyms
- PHMB;Polihexanide;PHMB(20%);Polihexanide HCl;Polyhexamethylene Biguanidine HCl;BG 1;BG-IR;99%PHMB;PHMB 98;Lavasept
- CBNumber:
- CB3511879
- Molecular Formula:
- C10H23N5
- Molecular Weight:
- 213.32312
- MDL Number:
- MFCD22380012
- MOL File:
- 32289-58-0.mol
- MSDS File:
- SDS
| storage temp. | Inert atmosphere,Room Temperature |
|---|---|
| solubility | Water |
| form | Solid |
| color | White to off-white |
| InChI | InChI=1S/C10H23N5/c1-9(11)14-7-5-3-4-6-8-15-10(12)13-2/h3-8H2,1-2H3,(H2,11,14)(H3,12,13,15) |
| InChIKey | SAGIGHPRUJPLKX-UHFFFAOYSA-N |
| SMILES | C(=N)(C)NCCCCCCNC(=N)NC |
| CAS DataBase Reference | 32289-58-0(CAS DataBase Reference) |
| FDA UNII | 4XI6112496 |
| ATC code | D08AC05 |
| EPA Substance Registry System | Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride (32289-58-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS08,GHS09,GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H372-H317-H351-H318-H410-H302-H330 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P270-P301+P312-P330-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P260-P264-P270-P314-P501-P273-P391-P501-P280-P305+P351+P338-P310-P201-P202-P281-P308+P313-P405-P501 |
Poly(hexamethylenebiguanide)hydrochloride price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 089694 | Poly (hexamethylene biguanide) hydrochloride 95+% | 32289-58-0 | 25g | $115 | 2021-12-16 | Buy |
| Matrix Scientific | 089694 | Poly (hexamethylene biguanide) hydrochloride 95+% | 32289-58-0 | 100g | $348 | 2021-12-16 | Buy |
| Ambeed | A411573 | Poly(hexamethylenebiguanide)hydrochloride 20%inwater | 32289-58-0 | 1kg | $121 | 2021-12-16 | Buy |
| Ambeed | A411573 | Poly(hexamethylenebiguanide)hydrochloride 20%inwater | 32289-58-0 | 1g | $5 | 2021-12-16 | Buy |
| Ambeed | A411573 | Poly(hexamethylenebiguanide)hydrochloride 20%inwater | 32289-58-0 | 5g | $6 | 2021-12-16 | Buy |
Poly(hexamethylenebiguanide)hydrochloride Chemical Properties,Uses,Production
Description
PHMB is best known for its broad-spectrum antimicrobial and antifungal activity. It is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY). PHMB is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes. 
Application
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).
Safety
On the 20th of April 2018, the european commission decided to ban preservative uses of PHMB PT9 (Fibre, leather, rubber and polymerised materials preservatives). It’s still allowed for uses as disinfectants PT2 (Disinfectants and algaecides not intended for direct application to humans or animals). Furthermore, PHMB has been declared as a candidate for substitution by the ECHA.
Chemical Properties
Colorless to pale yellow solution
Chemical Properties
Poly(hexamethylenebiguanide) hydrochloride is also used as a surface disinfectant and is alleged to be suitable for skin disinfection. This compound has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect. Although it is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because it is less foamproducing under use conditions.
Uses
Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes
Preparation
The preparation method of Poly(hexamethylenebiguanide)hydrochloride:By a certain proportion of 1; the own bisguanides of 6-and catalyst join in reaction vessel; under nitrogen protection, said mixture is heated to 80-200 DEGC and reacts, react 2-24 hour; reaction terminates; cooling blowing, obtains poly hexamethylene biguanide, poly hexamethylene biguanide aqueous acid is neutralized to pH value 5-9; and performing filtering so as to obtain a polyhexamethylene biguanidine salt.
Biological Activity
Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.
Properties and Applications
Polyhexamethylene biguanide hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer. It is a water solution that can be used as a broad spectrum and high efficient disinfectant. It is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic. Because of its special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.
Poly(hexamethylenebiguanide)hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUXI HONOR SHINE CHEMICAL CO.,LTD | +86-0510-83593312 +8619805123561 | sales@honorshinechem.com | China | 67 | 58 |
| BLiT (Hefei)Chemical Co.,Ltd | +86-551-62622640 | sales@blitchem.com | China | 293 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | sales01@watsonbiotech.cn | China | 5822 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Shandong Juchuang Chemical Co., LTD | +undefined15030412209 | admin@juchuangchem.com | China | 387 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 970 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
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View Lastest Price from Poly(hexamethylenebiguanide)hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-23 | Poly(hexamethylenebiguanide)hydrochloride
32289-58-0
|
US $99.00-66.00 / kg | 0.0010000000474974513kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-22 | Phlyhexamethylene biguanidine
32289-58-0
|
US $45.00 / kg | 1kg | 95% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-22 | Poly(hexamethylenebiguanide)hydrochloride
32289-58-0
|
US $0.00-0.00 / kg | 1kg | 99% | 20MT | Watson Biotechnology Co.,Ltd |
-
- Poly(hexamethylenebiguanide)hydrochloride
32289-58-0
- US $99.00-66.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Phlyhexamethylene biguanidine
32289-58-0
- US $45.00 / kg
- 95%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Poly(hexamethylenebiguanide)hydrochloride
32289-58-0
- US $0.00-0.00 / kg
- 99%
- Watson Biotechnology Co.,Ltd