Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl-

Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl-

Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Structure
Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- structure
CAS No.
2009343-14-8
Chemical Name:
Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl-
Synonyms
PHD-1-IN-1;Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl-;pocket,ion,Arg367-out,HIF-PH,Hypoxia-inducible factors,site,active,PHD 1 IN 1,orally,Inhibitor,PHD-1,Fe2+,PHD1IN1,iron,HIF/HIF Prolyl-Hydroxylase,HIFs,inhibit
CBNumber:
CB35954015
Molecular Formula:
C13 H8 N4
Molecular Weight:
220.23
MDL Number:
MFCD34470407
MOL File:
2009343-14-8.mol
Last updated:2024-07-02 08:55:06
Request For Quotation

Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Properties

storage temp. Store at -20°C
solubility DMSO : 195 mg/mL (885.44 mM; Need ultrasonic)
form Solid
color White to off-white

Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Chemical Properties,Uses,Production

Biological Activity

PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an "Arg367-out" pocket[1]. PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng?h/mL, Kp,uu of 1.11 and B/P of 0.95[1].

References

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jul 13;60(13):5663-5672.

Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4287 55
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 384 55
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9929 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9412 58
Jinan Jiuli Biotechnology Co. , Ltd. 486064515 486064515@qq.com China 2574 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 vip@med-life.cn China 5012 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9274 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai Chaolan Chemical Technology Center 58
DC Chemicals 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
RD International Technology Co., Limited 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Benzonitrile, 4-[1,2,4]triazolo[1,5-a]pyridin-5-yl- PHD-1-IN-1 pocket,ion,Arg367-out,HIF-PH,Hypoxia-inducible factors,site,active,PHD 1 IN 1,orally,Inhibitor,PHD-1,Fe2+,PHD1IN1,iron,HIF/HIF Prolyl-Hydroxylase,HIFs,inhibit 2009343-14-8