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ChemicalBook >> CAS DataBase List >>N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester

N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester

N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester Structure
N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester structure
CAS No.
1256490-54-6
Chemical Name:
N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester
Synonyms
-deoxy-3’-fluoro-2’N-[[P(S),2’-methyl-P-phenyl-5’-uridylyl]-L-alanine1-MethylethylEster;-O-[(1,1-dimethylethyl)dimethylsilyl]-2’L-Alanine, N-[[P(S),2'R]-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester;N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester
CBNumber:
CB36075582
Molecular Formula:
C28H43FN3O9PSi
Molecular Weight:
643.72
MDL Number:
MOL File:
1256490-54-6.mol
Last updated:2023-04-23 13:52:06
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N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester Properties

Density 1.24±0.1 g/cm3(Predicted)
solubility Chloroform, Dichloromethane, Methanol
pka 9.39±0.10(Predicted)
form Solid
color White

N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D233030 N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine1-MethylethylEster 1256490-54-6 2.5mg $165 2021-12-16 Buy
TRC D233030 N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine1-MethylethylEster 1256490-54-6 5mg $275 2021-12-16 Buy
TRC D233030 N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine1-MethylethylEster 1256490-54-6 10mg $495 2021-12-16 Buy
TRC D233030 N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine1-MethylethylEster 1256490-54-6 25mg $1155 2021-12-16 Buy
Product number Packaging Price Buy
D233030 2.5mg $165 Buy
D233030 5mg $275 Buy
D233030 10mg $495 Buy
D233030 25mg $1155 Buy

N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester Chemical Properties,Uses,Production

Uses

N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44808 58
Supplier Advantage
Energy Chemical 58
N-[[P(S),2''R]-2''-deoxy-3''-O-[(1,1-dimethylethyl)dimethylsilyl]-2''-fluoro-2''-methyl-P-phenyl-5''-uridylyl]-L-alanine 1-Methylethyl Ester L-Alanine, N-[[P(S),2'R]-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester -uridylyl]-L-alanine1-MethylethylEster -O-[(1,1-dimethylethyl)dimethylsilyl]-2&rsquo -deoxy-3&rsquo -fluoro-2&rsquo -methyl-P-phenyl-5&rsquo N-[[P(S),2&rsquo 1256490-54-6 C28H43FN3O9PSi