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CU-32

CU-32 Structure
CU-32 structure
CAS No.
2400954-16-5
Chemical Name:
CU-32
Synonyms
CU-32;CU32,CU 32;methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate;1,3,5-Triazine-2-carboxylic acid, 4-amino-6-[(4-iodophenyl)amino]-, methyl ester
CBNumber:
CB36198003
Molecular Formula:
C11H10IN5O2
Molecular Weight:
371.13
MDL Number:
MOL File:
2400954-16-5.mol
Last updated:2023-05-21 10:59:17
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CU-32 Properties

Boiling point 537.0±52.0 °C(Predicted)
Density 1.880±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml
form A crystalline solid
pka 3.11±0.10(Predicted)

CU-32 Chemical Properties,Uses,Production

Biological Activity

CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50 = 0.45 μM).1 It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM.

References

1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)

CU-32 Preparation Products And Raw materials

Raw materials

Preparation Products

CU-32 Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
ChemeGen 中国 18818260767 sales@chemegen.com China 6975 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 sales@tybiochem.com China 5593 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
ChemeGen 中国 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CU-32 CU32,CU 32 1,3,5-Triazine-2-carboxylic acid, 4-amino-6-[(4-iodophenyl)amino]-, methyl ester methyl 4-amino-6-((4-iodophenyl)amino)-1,3,5-triazine-2-carboxylate 2400954-16-5