Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>PYRILAMINE MALEATE

PYRILAMINE MALEATE

PYRILAMINE MALEATE Structure
PYRILAMINE MALEATE structure
CAS No.
59-33-6
Chemical Name:
PYRILAMINE MALEATE
Synonyms
paramal;pymafed;antihist;minihist;Histatex;pyraninyl;renstamin;BiMaleate;pyramaleate;stangenmaleate
CBNumber:
CB3677373
Molecular Formula:
C21H27N3O5
Molecular Weight:
401.46
MDL Number:
MFCD00069333
MOL File:
59-33-6.mol
Last updated:2024-12-18 14:08:52
Request For Quotation

PYRILAMINE MALEATE Properties

Melting point 101-103°C
storage temp. 2-8°C
solubility Very soluble in water, freely soluble in ethanol (96 per cent).
form Solid
color White
Water Solubility Soluble in water at 100mg/ml
λmax 310nm(EtOH)(lit.)
Merck 14,7984
Stability Stability Combustible. Incompatible with strong oxidizing agents.
LogP 2.751 (est)
CAS DataBase Reference 59-33-6(CAS DataBase Reference)
FDA 21 CFR 310.545; 341.12
FDA UNII R35D29L3ZA
EPA Substance Registry System Pyrilamine maleate (59-33-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36/37
WGK Germany  3
RTECS  UT1225000
TSCA  Yes
HS Code  2933399090
Toxicity LD50 orally in mice: 338 mg/kg (Hunziker)
NFPA 704
0
2 0

PYRILAMINE MALEATE price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P5514 Pyrilamine maleate salt 59-33-6 5g $74.1 2024-03-01 Buy
Sigma-Aldrich 1588004 Pyrilamine maleate United States Pharmacopeia (USP) Reference Standard 59-33-6 200mg $360 2024-03-01 Buy
TCI Chemical P2369 Pyrilamine Maleate >98.0%(HPLC)(T) 59-33-6 5g $39 2024-03-01 Buy
TCI Chemical P2369 Pyrilamine Maleate >98.0%(HPLC)(T) 59-33-6 25g $113 2024-03-01 Buy
Alfa Aesar J63247 Pyrilamine maleate 59-33-6 25g $124.65 2024-03-01 Buy
Product number Packaging Price Buy
P5514 5g $74.1 Buy
1588004 200mg $360 Buy
P2369 5g $39 Buy
P2369 25g $113 Buy
J63247 25g $124.65 Buy

PYRILAMINE MALEATE Chemical Properties,Uses,Production

Description

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.

Chemical Properties

solid

Uses

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Uses

A histamine H1 receptor antagonist

Uses

Mepyramine maleate is used as bulk pharmaceutical (antihistaminic). Product Data Sheet

brand name

Histavet-P [Veterinary] (Schering-Plough Animal Health); Pymafed (HoechstRoussel).

General Description

Pyrilamine, 2-[4-methoxybenzyl[2-dimethylamino)ethyl]-amino]pyridine, is available as theacid maleate salt (1:1), which is a white crystalline powderwith a faint odor and a bitter, saline taste. The salt is solublein water (1:0.4) and freely soluble in alcohol. A 10% solutionhas a pH of approximately 5. At a pH of 7.5 or above,the free base begins to precipitate.
Pyrilamine differs structurally from tripelennamine byhaving a methoxy group in the para position of the benzylradical. It differs from its more toxic and less potent precursorphenbenzamine (Antergan) by having a 2-pyridyl groupon the nitrogen atom in place of a phenyl group.
Clinically, pyrilamine and tripelennamine are consideredamong the less potent antihistaminics. They are highly potent,however, in antagonizing histamine-induced contractionsof guinea pig ileum. Because of the pronounced localanesthetic action, the drug should not be chewed, but takenwith food.

General Description

White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.

Air & Water Reactions

Water soluble.

Reactivity Profile

PYRILAMINE MALEATE is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of exposure to PYRILAMINE MALEATE may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.

Fire Hazard

Flash point data for PYRILAMINE MALEATE are not available, however PYRILAMINE MALEATE is probably combustible.

Biological Activity

Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Biochem/physiol Actions

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.

Safety Profile

A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects; predominantly used in horses.

storage

Room temperature

PYRILAMINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

PYRILAMINE MALEATE Suppliers

Global( 198)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15352 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Henan Alfa Chemical Co., Ltd 		China 10947 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
PT CHEM GROUP LIMITED 		+86-85511178; +86-85511178; peter68@ptchemgroup.com China 35425 58
Supplier Advantage
career henan chemical co 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu Medichem Co. Ltd 		58
AFINE CHEMICALS LIMITED 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Henan Alfa Chemical Co., Ltd 		58
TargetMol Chemicals Inc. 		58
PT CHEM GROUP LIMITED 		58

View Lastest Price from PYRILAMINE MALEATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mepyramine maleate pictures 2024-11-16 Mepyramine maleate
59-33-6
 US $55.00 / mg 99.71% 10g TargetMol Chemicals Inc.
Mepyramine maleate pictures 2024-11-16 Mepyramine maleate
59-33-6
 US $55.00 / mg 99.71% 10g TargetMol Chemicals Inc.
PYRILAMINE MALEATE pictures 2019-07-12 PYRILAMINE MALEATE
59-33-6
 US $1.00 / KG 1KG 99% 25kg Career Henan Chemical Co

PYRILAMINE MALEATE Spectrum

PYRILAMINE MALEATE(59-33-6)1HNMR

59-33-6(PYRILAMINE MALEATE)Related Search:

FORMANILIDE 4-Aminodiphenylamine 2-Benzylaminopyridine 2-(4-Methoxybenzylamino)pyridine PYRILAMINE
2-DIETHYLAMINOPYRIDINE Tripelennamine N,N'-Dimethyl-1,2-ethanediamine (METHOXYMETHYL)DIPHENYLPHOSPHINE OXIDE N,N-Dimethylethylenediamine
PYRILAMINE MALEATE Ammonium hydrogen maleate N-METHYL-N-PYRIDIN-2-YLETHANE-1,2-DIAMINE N-2-Pyridinyl-1,2-ethanediamine N'-(5-AMINOPENTYL)-N-(4-METHOXYBENZYL)-N'-METHYL-N-2-PYRIDINYL-1,2-ETHANEDIAMINE, DIMALEATE SALT
2-(ETHYLMETHYLAMINO)PYRIDINE N-(4-Methoxybenzyl)-N-2-pyridinyl-1,2-ethanediamine [[(2-aminoethyl)amino]methyl]phenol

1of4

MEPYRAMINE MALEATE MEPYRAMINE MALEATE SALT n-dimethylaminoethyl-n-p-methoxy-alpha-aminopyridinemaleate neo-anterganmeleate n-p-methoxybenzyl-n’-n’-dimethyl-n-alpha-pyridylethylenediaminemaleate paramal paraminylmaleate pymafed pyramaleate pyranilaminemaleate pyraninyl pyrilaminemaleatecrystalline renstamin stangenmaleate statominmaleate thylogenmaleate PYRILAMINE MALEATE METHANOL SOLUTION 2-((2-Dimethylaminoethyl)-(p-methoxybenzyl)amino)p(mepyraminemaleate) 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE PYRILAMINE MALEATE PYRILAMINE MALEATE SALT PYRANISAMINE MALEATE N-(P-METHOXYBENZYL)-N',N'-DIMETHYL-N-2-PYRIDYLETHYLENEDIAMINE MALEATE N-[4-METHOXY-PHENYL]METHYL-N',N'-DIMETHYL-N[2-PYRIDINYL]-1,2-ETHANEDIAMINE MALEATE SALT antihist diaminidemaleate minihist n-((4-methoxyphenyl)methyl)-n,n’-dimethyl-n-2-pyridinyl-2-ethanediamine n,n-dimethyl-n’-(4-methoxybenzyl)-n’-(2-pyridyl)ethylenediaminemaleate (z)-2-butenedioat 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-,(Z)-2-butenedioate(1:1) 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridinebimaleate 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinmaleate(1:1) 2786r.p.maleate 2-ethanediamine,n-[(4-methoxyphenyl)methyl]-n’,n’-dimethyl-n-2-pyridinyl-( anisopyradamine anthisanmaleate 1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1) PYRILAMINEMALEATE,USP Histatex Pyrilaminmaleat 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin maleate 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE USP PYRILAMINE MALEATE USP/NF Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-Nμ,Nμ-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt Pyrilamine Maleate (200 mg) BiMaleate N-[(4-Methoxyphenyl)Methyl]-N',N'-diMethyl-N-2-pyridinyl- 1,2-ethanediaMine (2Z)-2-Butenedioate N1-[(4-Methoxyphenyl)Methyl]-N2,N2-diMethyl-N1-2-pyridinyl-1,2-ethanediaMine (2Z)-2-Butenedioate N1-(4-Methoxybenzyl)-N2,N2-diMethyl-N1-(pyridin-2-yl)ethane-1,2-diaMine fuMarate Mepyramine maleate CRS N-(4-Methoxybenzyl)-N′,N′-dimethyl-N-(pyridin-2- yl)ethane-1,2-diamine (Z)-butenedioate N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine maleate PyrilamineMaleateSal N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate PYRILAMINE MALEATE USP/EP/BP Mepyramine maleateQ: What is Mepyramine maleate Q: What is the CAS Number of Mepyramine maleate Q: What is the storage condition of Mepyramine maleate Q: What are the applications of Mepyramine maleate Pyrilamine Maleate (1588004)