Afloqualone
- CAS No.
- 56287-74-2
- Chemical Name:
- Afloqualone
- Synonyms
- H-495;aroft;HQ-495;HQ 495;arofuto;Aoqualone;AFLOQUALONE;Afloquanone;Afloqualone D7;Afloqualone USP/EP/BP
- CBNumber:
- CB3699964
- Molecular Formula:
- C16H14FN3O
- Molecular Weight:
- 283.3
- MDL Number:
- MFCD00867693
- MOL File:
- 56287-74-2.mol
| Melting point | 195-196°C |
|---|---|
| Boiling point | 492.5±55.0 °C(Predicted) |
| Density | 1.2529 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 2.73±0.70(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C16H14FN3O/c1-10-4-2-3-5-14(10)20-15(9-17)19-13-7-6-11(18)8-12(13)16(20)21/h2-8H,9,18H2,1H3 |
| InChIKey | VDOSWXIDETXFET-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(N)C=C2)C(=O)N(C2=CC=CC=C2C)C=1CF |
| CAS DataBase Reference | 56287-74-2(CAS DataBase Reference) |
| FDA UNII | CO4U2C8ORZ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 315.1 i.p. (Tani) | |||||||||
| NFPA 704 |
|
Afloqualone price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21834 | Afloqualone ≥98% | 56287-74-2 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 21834 | Afloqualone ≥98% | 56287-74-2 | 5mg | $355 | 2024-03-01 | Buy |
| TRC | A357700 | Afloqualone | 56287-74-2 | 1g | $300 | 2021-12-16 | Buy |
| Matrix Scientific | 143959 | 6-Amino-2-(fluoromethyl)-3-(o-tolyl)quinazolin-4(3H)-one 95% | 56287-74-2 | 1g | $800 | 2021-12-16 | Buy |
| Matrix Scientific | 143959 | 6-Amino-2-(fluoromethyl)-3-(o-tolyl)quinazolin-4(3H)-one 95% | 56287-74-2 | 5g | $2332 | 2021-12-16 | Buy |
Afloqualone Chemical Properties,Uses,Production
Description
Afloqualone is a centrally acting muscle relaxant useful in the management of various spastic conditions, including cerebral palsy, cervical spondylosis, and multiple sclerosis. It is closely related to the hypnotidsedative methaqualone.
Description
Afloqualone (Item No. 21834) is an analytical reference standard categorized as a quinazolinone. This product is intended for research and forensic applications.
Originator
Tanabe (Japan)
Uses
Afloqualone acts as a muscle relaxant in humans and may be used in the treatment of muscle spasms affecting rheumatoid arthritis.
Definition
ChEBI: Afloqualone is an organic molecular entity.
Manufacturing Process
14.4 g (0.053 mol) of N-(2-amino-5-nitrobenzoyl)-o-toluidine and 6.3 g (0.08
mol) of pyridine are dissolved in 300 ml of tetrahydrofuran. 12.2 g (0.126
mol) of fluoroacetyl chloride are added to the solution for 10 minutes under
ice-cooling. The solution is stirred at the same temperature for 30 minutes
and then at room temperature for 2.5 hours. The reaction solution is allowed
to stand at room temperature overnight. The crystalline precipitate is collected
by filtration, washed with water and then dried. 16.4 g of N-(2-
fluoroacetamido-5-nitrobenzoyl)-o-toluidine are obtained. Yield: 93.7%; MP
238-239°C.
16.5 g (0.05 mol) of N-(2-fluoroacetamido-5-nitrobenzoyl)-o-toluidine and
25.5 g (0.25 mol) of acetic acid anhydride are dissolved in 250 ml of glacial
acetic acid. The solution is refluxed for 2 hours under heating. Then, the
reaction solution is evaporated to remove solvent. The residue thus obtained
is poured into ice-water, and the aqueous mixture is adjusted to pH 9 with
potassium carbonate. The crystalline precipitate is collected by filtration. 15.5
g of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-quinazolinone are obtained.
Yield: 98.7%; MP 155-158°C (recrystallized from ethanol).
A mixture of 2.0 g (0.064 mol) of 2-fluoromethyl-3-(o-tolyl)-6-nitro-4(3H)-
quinazolinone, 0.2 g of 5% palladium-carbon and 100 ml of acetic acid is
shaken for 30 minutes in hydrogen gas. The initial pressure of hydrogen gas is
adjusted to 46 lb and the mixture is heated with an infrared lamp during the
reaction. After 30 minutes of this reaction, the pressure of hydrogen gas
decreases to 6 lb. After the mixture is cooled, the mixture is filtered to
remove the catalyst. The filtrate is evaporated to remove acetic acid, and the
residue is dissolved in chloroform. The chloroform solution is washed with 5%
aqueous sodium hydroxide and water, successively. Then, the solution is dried
and evaporated to remove solvent. The oily residue thus obtained is dissolved
in 2 ml of chloroform, and the chloroform solution is passed through a column
of 200 g of silica gel. The silica gel column is eluted with ethyl acetatebenzene
(1:1). Then, the eluate is evaporated to remove solvent. The crude
crystal obtained is washed with isopropyl ether and recrystallized from isopropanol. 0.95 g of 2-fluoromethyl-3-(o-tolyl)-6-amino-4(3H)-quinazolinone
is obtained. Yield: 52.5%; MP 195-196°C.
brand name
AROFUTO
Therapeutic Function
Muscle relaxant
Afloqualone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jinhuan Chemical CO.,LTD. | +86-21-52210535 +8613162045318 | sales@jinhchem.com | China | 331 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
View Lastest Price from Afloqualone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-08 | Afloqualone USP/EP/BP
56287-74-2
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | Afloqualone
56287-74-2
|
US $1.00 / kg | 1kg | 99% | 100KG | Career Henan Chemical Co |
-
- Afloqualone USP/EP/BP
56287-74-2
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Afloqualone
56287-74-2
- US $1.00 / kg
- 99%
- Career Henan Chemical Co