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Tetrahydro-4H-pyran-4-one

Tetrahydro-4H-pyran-4-one structure

CAS No.: 29943-42-8

Chemical Name:: Tetrahydro-4H-pyran-4-one

Synonyms: dihydro-2H-pyran-4(3H)-one;Oxan-4-one;TETRAHYDROPYRAN-4-ONE;4-THP;4-OXOTETRAHYDROPYRAN;4H-Pyran-4-one, tetrahydro-;EOS-60523;1KG,10KG,25KG;TETRAHYDRO-GAMM;4-Oxacyclohexanone

CBNumber:: CB3703050

Molecular Formula:: C5H8O2

Molecular Weight:: 100.12

MDL Number:: MFCD00006581

MOL File:: 29943-42-8.mol

MSDS File:: SDS

Last updated:2024-10-31 13:32:20

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Tetrahydro-4H-pyran-4-one Properties

Boiling point	166-166.5 °C (lit.)
Density	1.084 g/mL at 25 °C (lit.)
refractive index	n20/D 1.452(lit.)
Flash point	134 °F
storage temp.	Inert atmosphere,Room Temperature
form	Liquid
color	Clear colorless to pale yellow
Water Solubility	MISCIBLE
BRN	106463
InChIKey	JMJRYTGVHCAYCT-UHFFFAOYSA-N
CAS DataBase Reference	29943-42-8(CAS DataBase Reference)
NIST Chemistry Reference	4H-Pyran-4-one, tetrahydro-(29943-42-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 1224 3/PG 3

WGK Germany

Hazard Note

Keep Cold/Flammable/Irritant

HazardClass

3.2

PackingGroup

III

HS Code

29329995

NFPA 704

	2
1		0

Tetrahydro-4H-pyran-4-one price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	198242	Tetrahydro-4H-pyran-4-one 99%	29943-42-8	1g	$41.9	2024-03-01	Buy
Sigma-Aldrich	198242	Tetrahydro-4H-pyran-4-one 99%	29943-42-8	5g	$135	2024-03-01	Buy
TCI Chemical	T1806	Tetrahydro-4H-pyran-4-one >95.0%(GC)	29943-42-8	1g	$37	2024-03-01	Buy
TCI Chemical	T1806	Tetrahydro-4H-pyran-4-one >95.0%(GC)	29943-42-8	5g	$104	2024-03-01	Buy
Alfa Aesar	A19010	Tetrahydro-4H-pyran-4-one 98%	29943-42-8	1g	$41.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
198242	1g	$41.9	Buy
198242	5g	$135	Buy
T1806	1g	$37	Buy
T1806	5g	$104	Buy
A19010	1g	$41.65	Buy

Tetrahydro-4H-pyran-4-one Chemical Properties,Uses,Production

Description

Tetrahydro-4H-pyran-4-one is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes.
The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. Tetrahydro-4H-pyran-4-one is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3.

Application

Tetrahydro-4-pyrone is used in organic synthesis as a building block for more complex chemical structures because it participates in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid and it undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of penicillins and in a ring of vitamin D3. Additionally, tetrahydro-4-pyrone is used as solvents in some reactions.

Chemical Properties

colorless to light yellow liquid

Uses

Tetrahydro-4-pyrone is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions.

Purification Methods

Purify the pyrone by repeated distillation, preferably in a vacuum. [Baker J Chem Soc 296 1944, IR: Olsen & Bredoch Chem Ber 91 1589 1958.] The oxime has m 87-88o and b 110-111o/13mm [Cornubert et al. Bull Soc Chim Fr 36 1950]. The 4-nitrophenylhydrazone forms orange-brown needles from EtOH, m 186o [Cawley & Plant J Chem Soc 1214 1938]. [Beilstein 17 I 131, 17 II 287, 17 III/IV 4171, 17/9 V 21.]

Tetrahydro-4H-pyran-4-one synthesis

Synthesis of Tetrahydro-4H-pyran-4-one from Carbon dioxide and 2,2'-Dichlorodiethyl ether

Tetrahydro-4H-pyran-4-one Preparation Products And Raw materials

Raw materials

Heptane Ethylene Copper Ethanol Acetone

Phosphoric acid Diethyl oxalate Nickel 2,2'-Bipyridine Sodium ethoxide

1,2,3,4-Tetrahydronaphthalene Sodium phosphate monobasic Aluminum chloride Dibutyl phthalate Ethyl acetate

Hydrochloric acid Dichloromethane Sodium hydroxide 3-Chloropropionyl chloride Magnesium sulfate

PETROLEUM ETHER

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Preparation Products

4-Aminotetrahydropyran hydrochloride 4-Aminotetrahydropyran 2-(TETRAHYDRO-PYRAN-4-YL)-ETHANOL E-4-Hexen-1-ol

Tetrahydro-4H-pyran-4-one Suppliers

Global( 493)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	+86-512-68780025 +8618962125825	sales@ryanchem.com	China	136	58
BTC pharm India	+918790379245	banny.janga@btcpharm.com	India	1262	58
Shanghai Yongzeng Technology Co.,Ltd	+86-021-65281118 +86-13818947575	sales@yongzchem.com	China	137	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12840	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18153	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504 +86-17332992504	sales8@hbganmiao.com	China	299	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29791	60

Supplier	Advantage
Suzhou Ryan Pharmachem Technology Co.,Ltd.	58
BTC pharm India	58
Shanghai Yongzeng Technology Co.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Weibang Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Hebei Ganmiao New material Technology Co., LTD	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60

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Tetrahydro-4H-pyran-4-one, pivotal in drug synthesis, aids in crafting potent histamine-3 antagonists for cognitive disorders,....
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Tetrahydro-4H-pyran-4-one: Synthesis and Potential Pharmaceutical Applications
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View Lastest Price from Tetrahydro-4H-pyran-4-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-22	Tetrahydro-4H-pyran-4-one 29943-42-8	US $65.00 / kg	1kg	99%	5000kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-11-22	Tetrahydro-4H-pyran-4-one 29943-42-8	US $0.00 / KG	1KG	99%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-04	Tetrahydro-4H-pyran-4-One 29943-42-8	US $370.00 / kg	1kg	99%min	100kgs	Shanghai Yongzeng Technology Co.,Ltd

Tetrahydro-4H-pyran-4-one
29943-42-8
US $65.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

Tetrahydro-4H-pyran-4-one
29943-42-8
US $0.00 / KG
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

Tetrahydro-4H-pyran-4-One
29943-42-8
US $370.00 / kg
99%min
Shanghai Yongzeng Technology Co.,Ltd

Tetrahydro-4H-pyran-4-one Spectrum

Tetrahydro-4H-pyran-4-one(29943-42-8)MS Tetrahydro-4H-pyran-4-one(29943-42-8)¹HNMR Tetrahydro-4H-pyran-4-one(29943-42-8)IR1 Tetrahydro-4H-pyran-4-one(29943-42-8)Raman

29943-42-8(Tetrahydro-4H-pyran-4-one)Related Search:

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Tetrahydropyranyl-4-acetic acid Tetrahydro-4H-Pyran-4-one TETRAHYDROPYRAN-2-METHANOL Ethyl Tetrahydropyran-4-Carboxylate ETHYL TETRAHYDROPYRAN-4-YL-ACETATE

(TETRAHYDRO-FURAN-3-YL)-ACETIC ACID Tetrahydropyran-4-carbaldehyde Tetrahydro-2H-pyran-4-carbonyl chloride

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Tetrahydro-4-pyrone TETRAHYDRO-GAMMA-PYRONE TETRAHYDRO-4H-PYRAN-4-ONE TETRAHYDRO-2H-PYRAN-4-ONE TetrahydroHpyranone Tetrahydropyran-4-on Tetrahydro-4H-pyran-4-one,98% Tetrahydo-4H-pyran-4-one Tetrahydro-4H-pyran-4-one 97% Tetranydropyran-4-one Tetrahydro-4-H-prran-one Tetrahydro-4H-pran-4-one Tetrahydro-4H-pyran-4-one, 97+% Four hydrogen pyran - 4 - ketone Tetrahydro-4H-pyran-4-one 4-tetrahydropyranone 2,3,5,6-Tetrahydropyran-4-one 3,5,6-Trihydro-2H-pyran-4-one 4-Oxotetrahydopyran 2,3,5,6-Tetrahydro-4H-pyran-4-one 2,3,5,6-Tetrahydro-4-pyranone 4-Oxacyclohexanone Tetrahydro-4-pyranone Tetrahydro-4H-pyran-4-one,99% Tetrahydro-4H-pyran-4-one,4-Oxotetrahydropyran Tetrahydro-4H-pyran- 4-Oxotetrahydropyran(Tetrahydropyran-4-one) etrahydro-4H-pyran-4-one Tetrahydro-4H-pyran-4-one, 99% 5GR TETRAHYDRO-4H-PYRAN-4-ONE FOR SYNTHESIS 4-Oxotrtrahydropyran 4-Oxotetrahydro-4H-pyran Tetrahydro-4H-Pyran-4-One (4-THP) EOS-60523 TETRAHYDRO-GAMM 1KG,10KG,25KG Tetrahydro-4H-pyran-4-one, 98%, for synthesis Tetrahydro-4H-pyran-4-one ISO 9001：2015 REACH TETRAHYDROPYRAN-4-ONE 4-OXOTETRAHYDROPYRAN 4-THP 4H-Pyran-4-one, tetrahydro- Oxan-4-one dihydro-2H-pyran-4(3H)-one Tetrahydropyranone 29943-42-8 C5H8O2 KETONE Building Blocks Heterocyclic Building Blocks Pyrans blocks Oxygen cyclic compounds Pyrans, Piperidines &Piperazines Carbonyl Compounds Ketone Pyrans, Piperidines & Piperazines Heterocycles