3-Chloropropionyl chloride
- CAS No.
- 625-36-5
- Chemical Name:
- 3-Chloropropionyl chloride
- Synonyms
- 3-Chloropropanoyl chloride;Chloropropionyl chloride;oropropionyL;3-Chloropropionyl ch;3-Chlorpropionylchlorid;-Chloropropanoylchloride;3-Chloropropinyl chloride;3-chloro-propanoylchlorid;3'ChloropropionylChloride;3-CHLOROPROPIONYL CHLORIDE
- CBNumber:
- CB8691211
- Molecular Formula:
- C3H4Cl2O
- Molecular Weight:
- 126.97
- MDL Number:
- MFCD00000747
- MOL File:
- 625-36-5.mol
- MSDS File:
- SDS
| Melting point | -32 °C |
|---|---|
| Boiling point | 143-145 °C(lit.) |
| Density | 1.33 g/mL at 25 °C(lit.) |
| vapor pressure | 10.0 hPa |
| refractive index |
n |
| RTECS | UC3934000 |
| Flash point | 146 °F |
| storage temp. | Flammables area |
| solubility | Chloroform, Ethyl Acetate |
| form | liquid |
| color | red-brown |
| PH | <7 (H2O) |
| explosive limit | 8.8-20.2%(V) |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| BRN | 635814 |
| Stability | Moisture Sensitive |
| InChIKey | INUNLMUAPJVRME-UHFFFAOYSA-N |
| CAS DataBase Reference | 625-36-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 24PO18998I |
| NIST Chemistry Reference | Propanoyl chloride, 3-chloro-(625-36-5) |
| EPA Substance Registry System | Propanoyl chloride, 3-chloro- (625-36-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314-H330 | |||||||||
| Precautionary statements | P260-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 14-22-26-34-35-10 | |||||||||
| Safety Statements | 23-26-36/37/39-45-38-16-8 | |||||||||
| RIDADR | UN 3390 6.1/PG 1 | |||||||||
| WGK Germany | 1 | |||||||||
| F | 21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29159080 | |||||||||
| NFPA 704 |
|
3-Chloropropionyl chloride price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C69128 | 3-Chloropropionyl chloride 98% | 625-36-5 | 100g | $137 | 2024-03-01 | Buy |
| Sigma-Aldrich | 147443 | 3-Chloropropionyl chloride technical grade | 625-36-5 | 100ml | $56.4 | 2024-03-01 | Buy |
| Alfa Aesar | B25698 | 3-Chloropropionyl chloride, 97% | 625-36-5 | 100g | $78.8 | 2024-03-01 | Buy |
| TRC | C380600 | 3-Chloropropionyl chloride | 625-36-5 | 5g | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC71810 | 3-Chloropropionyl chloride | 625-36-5 | 50g | $50 | 2021-12-16 | Buy |
3-Chloropropionyl chloride Chemical Properties,Uses,Production
Description
3-Chloropropionyl chloride is an important bifunctional reagent. It is capable of acylation and possesses a 2-chloro-ethyl fragment (CH2CH2Cl), which can be subjected to nucleophilic substitution and serves as a masked vinyl group. It can be used as a starting material in many reactions to construct a variety of (hetero)cyclic compounds.
Chemical Properties
Clear colorless to dark brown liquid. Soluble in ethanol, ether and chloroform. Slightly soluble in water.
Uses
3-Chloropropionyl chloride is a reagent used in the synthesis of Beclamide (B119400), which is a chlorinated benzylpropanamide used as an anticonvulsant drug. It is used in the treatment of tonic-clonic seizyres and has sedative properties.
Preparation
3-Chloropropionyl chloride (1) is commercially available and can be prepared from β-propiolactone (2) and thionyl chloride.1 Other standard methods available for the preparation of acyl chlorides can also be applied: the reaction of acrylic acid (3) or 3-chloropropionic acid (4) with thionyl chloride, phosphoryl chloride, phosgene, or phosphorus trichloride.
Reactions
(1) The Friedel¨CCrafts acylation of tert-butylbenzene (5) with 3-chloropropionyl chloride (1) followed by cyclization provid- ed indanone 6, which was further transformed into urea derivative 7, a potent TRPV1 antagonist. 
(2) A novel high-yielding one-pot microwave-assisted synthesis of condensed 5-substituted pyranoisoquinoline-1,6-diones 9 from 2-substituted isoquinoline-1,3-diones 8 and 3-chloropropionyl chloride (1) was reported. 
(3) Acylation of 2-aminophenol (12) with 3-chloropropionyl chloride (1), followed by cyclization in the presence of polyphosphoric acid (PPA), gave benzoxazole 13, which was further reacted with 4-chlorophenyl-1-piperazine to yield the target benzo[d]oxazole analogue 14, a selective dopamine D4 receptor ligand.
Flammability and Explosibility
Non flammable
Synthesis
3-Chloropropionyl chloride is produced by reaction of acrylic acid with hydrogen chloride and phosgene in the presence of, for example,dimethylformamide as catalyst, or by reaction of propiolactone with thionyl chloride.
3-Chloropropionyl chloride Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2158 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20287 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18779 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29884 | 58 |
View Lastest Price from 3-Chloropropionyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | 3-Chloropropionyl chloride
625-36-5
|
US $85.00-25.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-10-11 | 3-Chloropropionyl chloride
625-36-5
|
US $9.10 / KG | 1KG | 99.% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2024-03-03 | 3-Chloropropionyl Chloride
625-36-5
|
US $140.00 / Kg | 1Kg | 99 % | 500 Kg | R&D Scientific Inc. |
-
- 3-Chloropropionyl chloride
625-36-5
- US $85.00-25.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- 3-Chloropropionyl chloride
625-36-5
- US $9.10 / KG
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3-Chloropropionyl Chloride
625-36-5
- US $140.00 / Kg
- 99 %
- R&D Scientific Inc.
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