ChemicalBook >> CAS DataBase List >>Dimethyl malonate
Dimethyl malonate
- CAS No.
- 108-59-8
- Chemical Name:
- Dimethyl malonate
- Synonyms
- DMM;METHYL MALONATE;Dimethyl propanedioate;MALONIC ACID DIMETHYL ESTER;dimthyl malonate;dimethyl1,3-propanedioate;MINA-009;Malonic acid d;DIMETHYL MALONAT;DIMETHYL MALONATE
- CBNumber:
- CB3776436
- Molecular Formula:
- C5H8O4
- Molecular Weight:
- 132.11
- MDL Number:
- MFCD00008460
- MOL File:
- 108-59-8.mol
- MSDS File:
- SDS
Last updated:2024-11-19 23:02:33
| Melting point | -62 °C (lit.) |
|---|---|
| Boiling point | 180-181 °C (lit.) |
| Density | 1.156 g/mL at 25 °C (lit.) |
| vapor density | >1 (vs air) |
| vapor pressure | 0.15 hPa (20 °C) |
| refractive index |
n |
| Flash point | 194 °F |
| storage temp. | Store below +30°C. |
| solubility | alcohol: miscible |
| form | Liquid |
| pka | 11.80±0.46(Predicted) |
| color | Clear colorless |
| Odor | fruity |
| explosive limit | 1.3-17.4%(V) |
| Water Solubility | negligible |
| Merck | 14,6096 |
| BRN | 774261 |
| Dielectric constant | 10.4（20℃） |
| Stability | Stable. Incompatible with strong oxidizing agents. Flammable. |
| InChIKey | BEPAFCGSDWSTEL-UHFFFAOYSA-N |
| LogP | -0.05 at 20-25℃ and pH6.4 |
| CAS DataBase Reference | 108-59-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | EM8Y79998C |
| NIST Chemistry Reference | Propanedioic acid, dimethyl ester(108-59-8) |
| EPA Substance Registry System | Dimethyl malonate (108-59-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | OO0950000 | |||||||||
| Autoignition Temperature | 440 °C | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29171910 | |||||||||
| Toxicity | LD50 orally in Rabbit: 5331 mg/kg LD50 dermal Rabbit > 5000 mg/kg | |||||||||
| NFPA 704 |
|
Dimethyl malonate price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 100mL | $35.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 500mL | $64.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.00899 | Dimethyl malonate for synthesis | 108-59-8 | 1L | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | 136441 | Dimethyl malonate 98% | 108-59-8 | 1kg | $116 | 2024-03-01 | Buy |
| TCI Chemical | M0030 | Dimethyl Malonate >98.0%(GC) | 108-59-8 | 25g | $19 | 2024-03-01 | Buy |
Dimethyl malonate Chemical Properties,Uses,Production
Description
Dimethyl malonate is a diester derivative of malonic acid. It is a common reagent for organic synthesis used, for example, as a precursor for barbituric acid. It is also used in the malonic ester synthesis. It can be synthesized from dimethoxymethane and carbon monoxide.
Chemical Properties
liquid
Chemical Properties
Dimethyl malonate is soluble in alcohol and ether and very slightly soluble in water. It may slowly decompose.
Uses
It is used in fragrances and some artificial flavorings .
Uses
Dimethyl malonate is a reagent used in organic synthesis. It acts as a precursor for the synthesis of mono-substituted and di-substituted acetic acid, barbiturates, vitamin B1 and vitamin B6. It is used in the pharmaceutical industry to prepare pharmaceuticals like chloroquine and butazolidin. It is involved in the synthesis of diastereomeric pure thienylpyridines by reacting with 1,3-diphenylprop-2-enyl acetate.
Application
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate was used in gold catalyzed oxidative esterification of glycerol, 1,2-propanediol and 1,3-propanediol.
Production Methods
Dimethyl malonate is produced via direct esterification of methanol with malonic acid under azeotropic conditions.
General Description
Dimethyl malonate undergoes enantioselective palladium-catalyzed allylic substitution reaction with 1,3-diphenylprop-2-enyl acetate to yield diastereomeric pure thienylpyridines.
Dimethyl malonate Preparation Products And Raw materials
Raw materials
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Preparation Products
Dimethyl ethylmalonate
Methyl 3-cyclopentenecarboxylate
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER
2-Methylpyrimidine
DIMETHYL METHOXYMALONATE
Primisulfuron-methyl
5-Fluoro-2-oxindole
Pipemidic acid
5-(2-ETHYLTHIO PROPYL)-1,3-CYCLOHEXANEDIONE
3-(4-FLUOROPHENYL)PROPIONIC ACID
8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE
5-(TETRAHYDRO-2H-THIOPYRAN-3-YL)-1,3-CYCLOHEXANEDIONE
(1-Aminocyclopropyl)methanol
1,1-Cyclopropanedicarboxylic acid dimethyl ester
Chlorimuron-ethyl
ADS
DIMETHYL BROMOMALONATE
7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID METHYL ESTER
MALONIC ACID DI-N-BUTYL ESTER
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Global( 704)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Believe Chemical PTE.LTD | +86-18553607090 +8618553607090 | 1093908296@qq.com | China | 1667 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5892 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20286 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
| JINING XINHE CHEMICAL CO., LTD | +8615318402391 | sales@xinhepharma.com | China | 809 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18775 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
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View Lastest Price from Dimethyl malonate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-28 | Dimethyl malonate
108-59-8
|
US $0.00 / KG | 1KG | 99.5% | 1000mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2024-11-28 | Dimethyl malonate
108-59-8
|
US $10.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-11-19 | Dimethyl malonate
108-59-8
|
US $42.00 / mg | ≥95% | 10g | TargetMol Chemicals Inc. |
-
- Dimethyl malonate
108-59-8
- US $0.00 / KG
- 99.5%
- Jinan Finer Chemical Co., Ltd
-
- Dimethyl malonate
108-59-8
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Dimethyl malonate
108-59-8
- US $42.00 / mg
- ≥95%
- TargetMol Chemicals Inc.
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