(+)-EPIBATIDINE DIHYDROCHLORIDE
- CAS No.
- 148152-66-3
- Chemical Name:
- (+)-EPIBATIDINE DIHYDROCHLORIDE
- Synonyms
- CMI 545;(±)Epibatidine,(±) Epibatidine;(+/-)-EPIBATIDINE HYDROCHLORIDE;(+)-EPIBATIDINE DIHYDROCHLORIDE;2-(6-CHLORO-PYRIDIN-3-YL)-7-AZA-BICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, (1R,2R,4S)-rel-;(+/-)-EXO-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE;7-AZABICYCLO[2.2.1]HEPTANE, 2-(6-CHLORO-3-PYRIDINYL)-, DIHYDROCHLORIDE, EXO-;EXO[+/-]-2-[6-CHLORO-3-PYRIDINYL]-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;EXO-(+)-1R,2R,4S-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE
- CBNumber:
- CB3795844
- Molecular Formula:
- C11H13ClN2
- Molecular Weight:
- 208.69
- MDL Number:
- MFCD00923801
- MOL File:
- 148152-66-3.mol
- MSDS File:
- SDS
| Boiling point | 336.7±32.0 °C(Predicted) |
|---|---|
| Density | 1.223±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; <24.55mg/ml in ethanol |
| pka | 10.07±0.40(Predicted) |
| form | solid |
| color | Off White |
| Water Solubility | Soluble to 5 mM in water and to 100 mM in ethanol |
(+)-EPIBATIDINE DIHYDROCHLORIDE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | E582200 | (±)-Epibatidine | 148152-66-3 | 2.5mg | $195 | 2021-12-16 | Buy |
| TRC | E582200 | (±)-Epibatidine | 148152-66-3 | 5mg | $430 | 2021-12-16 | Buy |
| TRC | E582200 | (±)-Epibatidine | 148152-66-3 | 25mg | $1540 | 2021-12-16 | Buy |
| ApexBio Technology | B6406 | (±)-Epibatidine | 148152-66-3 | 10mg | $448 | 2021-12-16 | Buy |
(+)-EPIBATIDINE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Uses
(-)-Epibatidine has binding affinities for α4β2 and α3β4 nicotinic receptors.
Definition
ChEBI: 3-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane is an alkaloid.
Biological Activity
(+)-aj 76 hydrochloride is an antagonist of dopamine autoreceptor with pki values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hd3, hd4, hd2s, hd2l and rd2 receptors, respectively.dopamine receptor is a g protein-coupled receptor and mainly exists in the vertebrate central nervous system (cns). dopamine receptor is a receptor for dopamine and plays a critical role in memory, learning, pleasure, cognition, motivation and fine motor control.(+)-aj 76 hydrochloride is a dopamine receptor antagonist. in rats, aj76 stimulated locomotor activity and increased the levels of 3,4-dihydroxyphenylacetic acid (dopac) and hva in brain, which were dopamine metabolites [1]. in rats injected with cocaine, (+)-a j76 increased the locomotor stimulation during the first 30 min. however, (+)-aj76 inhibited the later more intense locomotor stimulation and cocaine-induced stereotypies [2]. in vivo, (+)-aj76 induced dopamine release mainly through interaction with dopamine receptors in the terminal regions of the a9 and a10 dopaminergic fibers. however, (+)-aj76 increased the level of dopac via the somatodendritic autoreceptors [3].
storage
Desiccate at +4°C
References
[1]. kullingsjö h, carlsson a, svensson k. effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-aj76, on locomotor activity and brain da metabolism in the rat. eur j pharmacol, 1991, 205(3): 241-246.
[2]. piercey mf, lum jt, hoffmann we, et al. antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-aj76 and (+)-uh232. brain res, 1992; 588(2): 217-222.
[3]. waters n, hansson l, löfberg l, et al. intracerebral infusion of (+)-aj76 and (+)-uh232: effects on dopamine release and metabolism in vivo. eur j pharmacol, 1994, 251(2-3): 181-190.
(+)-EPIBATIDINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-EPIBATIDINE DIHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20260 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8140 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10524 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5127 | 58 |
View Lastest Price from (+)-EPIBATIDINE DIHYDROCHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-08 | (+)-EPIBATIDINE DIHYDROCHLORIDE
148152-66-3
|
US $8.00-0.80 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- (+)-EPIBATIDINE DIHYDROCHLORIDE
148152-66-3
- US $8.00-0.80 / kg
- 99%
- Henan Fengda Chemical Co., Ltd